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The postulated innocuity of lifetime exposure to aluminium should be reappraised.终身接触铝的假定无害性应重新评估。
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2
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Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a (Al)Al microtracer approach: a follow-up study in humans.使用(Al)Al微量示踪剂方法评估代表性止汗剂配方中铝的皮肤吸收:一项人体随访研究。
Toxicol Res (Camb). 2022 May 31;11(3):511-519. doi: 10.1093/toxres/tfac029. eCollection 2022 Jun.
2
Chromosomal instability as a source of genomic plasticity.染色体不稳定性作为基因组可塑性的来源。
Curr Opin Genet Dev. 2022 Jun;74:101913. doi: 10.1016/j.gde.2022.101913. Epub 2022 May 5.
3
Dose-response relationships in aluminium toxicity in humans.人体铝中毒中的剂量-反应关系。
Clin Toxicol (Phila). 2022 Apr;60(4):415-428. doi: 10.1080/15563650.2022.2029879. Epub 2022 Feb 18.
4
Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number.铝进入哺乳动物细胞并破坏染色体结构和数量。
Int J Mol Sci. 2021 Sep 1;22(17):9515. doi: 10.3390/ijms22179515.
5
Role of metals in Alzheimer's disease.金属在阿尔茨海默病中的作用。
Metab Brain Dis. 2021 Oct;36(7):1627-1639. doi: 10.1007/s11011-021-00765-w. Epub 2021 Jul 27.
6
Aluminum toxicity and aluminum stress-induced physiological tolerance responses in higher plants.高等植物的铝毒性和铝胁迫诱导的生理耐受反应。
Crit Rev Biotechnol. 2021 Aug;41(5):715-730. doi: 10.1080/07388551.2021.1874282. Epub 2021 Apr 18.
7
Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis.基因组不稳定性是铝诱导肿瘤发生的早期事件。
Int J Mol Sci. 2020 Dec 7;21(23):9332. doi: 10.3390/ijms21239332.
8
Effect of propylene glycol on the skin penetration of drugs.丙二醇对药物经皮渗透的影响。
Arch Dermatol Res. 2020 Jul;312(5):337-352. doi: 10.1007/s00403-019-02017-5. Epub 2019 Nov 30.
9
Mechanisms of Genomic Instability in Breast Cancer.乳腺癌中基因组不稳定性的机制。
Trends Mol Med. 2019 Jul;25(7):595-611. doi: 10.1016/j.molmed.2019.04.004. Epub 2019 May 8.
10
Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a Al Microtracer Approach.采用 Al 微示踪剂法评估代表性止汗剂配方中铝的经皮吸收。
Clin Transl Sci. 2018 Nov;11(6):573-581. doi: 10.1111/cts.12579. Epub 2018 Jul 27.

终身接触铝的假定无害性应重新评估。

The postulated innocuity of lifetime exposure to aluminium should be reappraised.

作者信息

Mandriota Stefano J, Sappino André-Pascal

机构信息

Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, Chêne-Bougeries, Switzerland.

出版信息

Front Oncol. 2023 Jul 24;13:1159899. doi: 10.3389/fonc.2023.1159899. eCollection 2023.

DOI:10.3389/fonc.2023.1159899
PMID:37554161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10406518/
Abstract

Because of its chemical versatility and abundance in nature, aluminium is employed in a myriad of frequently used products - including cosmetics and food additives - and applications - drinking water purification procedures being an example. Despite what its widespread use might suggest, aluminium's harmlessness is a matter of debate in the scientific community. In this article we trace the lines of a growing questioning about the potential mutagenic effects of this metal, due to the data produced over the recent years, and with an eye to the discussions currently underway in this regard between the scientific community, industry, and regulatory bodies.

摘要

由于铝在化学性质上具有多样性且在自然界中储量丰富,它被用于众多常用产品——包括化妆品和食品添加剂——以及各种应用中,饮用水净化程序就是一个例子。尽管其广泛使用可能给人一种无害的印象,但铝的无害性在科学界仍是一个有争议的问题。在本文中,我们根据近年来产生的数据,着眼于科学界、行业和监管机构目前在这方面的讨论,梳理对这种金属潜在诱变效应质疑声渐高的脉络。