Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Turkey.
Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
J Appl Toxicol. 2021 Nov;41(11):1704-1718. doi: 10.1002/jat.4228. Epub 2021 Aug 15.
Usage of inorganic ingredients like aluminium salts in cosmetics and personal care products has been a concern for producers and consumers. Although aluminium is used to treat hyperhidrosis, some worries have been raised about aluminium's role in breast cancer, breast cyst and Alzheimer's disease. The human population is exposed to aluminium from vaccines, diet, and drinking water, but the frequent use of aluminium-based cosmetics might add additional local exposure. This paper reviews literature to determine if aluminium-based products may pose potential harm to the body. The dermal absorption of aluminium is not widely understood. It is not yet known whether aluminium can travel from the skin to brain to cause Alzheimer's disease. Aluminium may cause gene instability, alter gene expression or enhance oxidative stress, but the carcinogenicity of aluminium has not been proved yet. Until now, epidemiological researches were based on oral information, which lacks consistency, and the results are conflicting. Future studies should target real-life-based long-time exposure to antiperspirants and other aluminium-containing cosmetics and personal care products.
在化妆品和个人护理产品中使用无机成分(如铝盐)一直是生产商和消费者关注的问题。尽管铝被用于治疗多汗症,但人们对铝在乳腺癌、乳腺囊肿和阿尔茨海默病中的作用仍存在一些担忧。人类通过疫苗、饮食和饮用水接触铝,但频繁使用含铝的化妆品可能会增加局部接触。本文综述了文献,以确定含铝产品是否可能对身体造成潜在危害。皮肤对铝的吸收尚未被广泛了解。目前还不清楚铝是否可以从皮肤转移到大脑引起阿尔茨海默病。铝可能导致基因不稳定、改变基因表达或增强氧化应激,但铝的致癌性尚未得到证实。到目前为止,流行病学研究基于口头信息,这些信息缺乏一致性,结果相互矛盾。未来的研究应该针对实际生活中长时间使用止汗剂和其他含铝的化妆品和个人护理产品的情况。