PD 116,152，一种新型吩嗪类抗肿瘤抗生素。结构与抗肿瘤活性。

PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.

作者信息

Smitka T A, Bunge R H, Wilton J H, Hokanson G C, French J C, He C H, Clardy J

出版信息

J Antibiot (Tokyo). 1986 Jun;39(6):800-3. doi: 10.7164/antibiotics.39.800.

DOI:10.7164/antibiotics.39.800

Abstract

A new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. This compound, whose structure was determined by spectroscopic methods and verified by X-ray diffraction analysis, was found to be methyl 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylate.

摘要

从一种链霉菌属菌株的培养液中分离出一种具有抗肿瘤活性的新型高度取代吩嗪。通过光谱方法确定其结构并经X射线衍射分析验证，发现该化合物为6-甲酰基-4,7,9-三羟基-8-甲基-1-吩嗪羧酸甲酯。