Kelly John J, Desai Nimesh D, Patrick William L, Cannon Brittany J, Zhao Yu, Mosbahi Selim, Berezowksi Mikolaj, Iyengar Amit, Szeto Wilson Y, Bavaria Joseph E
Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Ann Cardiothorac Surg. 2023 Jul 31;12(4):318-325. doi: 10.21037/acs-2023-avs2-18. Epub 2023 Jul 7.
Debate still persists on whether valve-sparing root reimplantation (VSRR) of a very asymmetric bicuspid aortic valve (BAV) should be completed such that the asymmetry of the native commissural orientation is retained, or if it should be made symmetric (180°-180°). Herein, we present our approach, in which the native asymmetry is preserved, and the valve is reimplanted in a 210°-150° orientation.
A retrospective review was performed of 130 patients with BAV who underwent VSRR between January 1, 2004 and March 1, 2023 at a single institution. Of this total, 37 were reimplanted asymmetrically (210°-150°). The primary outcome was > moderate aortic insufficiency (AI). Secondary outcomes included severe aortic stenosis (AS), reintervention, and survival.
The included 37 patients were mostly male [94.6% (35/37)] with mean age of 46.3 years, and with low rates of comorbidities. At least moderate AI was present in 40.5% (15/37) prior to surgery. All BAV in this series were Sievers Type 1 with a mean commissural angle of 128.2°. Leaflet repair was required in 81.1% (30/37), most commonly involving central plication of the conjoined cusp [96.7% (29/30)] and raphe release [73.3% (22/30)]. There was no 30-day mortality or stroke. At 10 years, the cumulative incidences of > moderate AI, severe AS, and reintervention were 7.6% (0-17.2%), 7.1% (0-19.7%), and 5.3% (0.3-22%), respectively. There was no mortality for the entire duration of the study period.
This series demonstrates excellent 10-year outcomes of maintaining commissural orientation in asymmetric BAV reimplantation procedures. However, further study with additional patients, longer follow-up, and direct comparison to symmetric reimplantation for similar BAV morphology is required.
对于非常不对称的二叶式主动脉瓣(BAV)进行保留瓣膜的根部再植入术(VSRR)时,是应保留天然瓣叶交界方向的不对称性,还是应使其对称(180°-180°),目前仍存在争议。在此,我们介绍我们的方法,即保留天然的不对称性,并以210°-150°的方向进行瓣膜再植入。
对2004年1月1日至2023年3月1日在单一机构接受VSRR的130例BAV患者进行回顾性研究。其中,37例进行了不对称再植入(210°-150°)。主要结局为中重度主动脉瓣关闭不全(AI)。次要结局包括重度主动脉瓣狭窄(AS)、再次干预和生存率。
纳入的37例患者大多为男性[94.6%(35/37)],平均年龄46.3岁,合并症发生率较低。术前至少存在中重度AI的患者占40.5%(15/37)。本系列所有BAV均为Sievers 1型,平均瓣叶交界角为128.2°。81.1%(30/37)的患者需要进行瓣叶修复,最常见的是联合瓣叶的中央折叠[96.7%(29/30)]和嵴释放[73.3%(22/30)]。术后30天无死亡或卒中发生。10年时,中重度AI、重度AS和再次干预的累积发生率分别为7.6%(0-17.2%)、7.1%(0-19.7%)和5.3%(0.3-22%)。在整个研究期间无死亡病例。
本系列研究表明,在不对称BAV再植入手术中维持瓣叶交界方向可获得优异的10年结局。然而,需要对更多患者进行进一步研究,延长随访时间,并与类似BAV形态的对称再植入进行直接比较。