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采用再植入技术并维持瓣叶连合处方向进行主动脉瓣修复的结果。

Outcomes of aortic valve repair with the reimplantation technique and maintenance of commissural orientation.

作者信息

Kelly John J, Desai Nimesh D, Patrick William L, Cannon Brittany J, Zhao Yu, Mosbahi Selim, Berezowksi Mikolaj, Iyengar Amit, Szeto Wilson Y, Bavaria Joseph E

机构信息

Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Ann Cardiothorac Surg. 2023 Jul 31;12(4):318-325. doi: 10.21037/acs-2023-avs2-18. Epub 2023 Jul 7.

Abstract

BACKGROUND

Debate still persists on whether valve-sparing root reimplantation (VSRR) of a very asymmetric bicuspid aortic valve (BAV) should be completed such that the asymmetry of the native commissural orientation is retained, or if it should be made symmetric (180°-180°). Herein, we present our approach, in which the native asymmetry is preserved, and the valve is reimplanted in a 210°-150° orientation.

METHODS

A retrospective review was performed of 130 patients with BAV who underwent VSRR between January 1, 2004 and March 1, 2023 at a single institution. Of this total, 37 were reimplanted asymmetrically (210°-150°). The primary outcome was > moderate aortic insufficiency (AI). Secondary outcomes included severe aortic stenosis (AS), reintervention, and survival.

RESULTS

The included 37 patients were mostly male [94.6% (35/37)] with mean age of 46.3 years, and with low rates of comorbidities. At least moderate AI was present in 40.5% (15/37) prior to surgery. All BAV in this series were Sievers Type 1 with a mean commissural angle of 128.2°. Leaflet repair was required in 81.1% (30/37), most commonly involving central plication of the conjoined cusp [96.7% (29/30)] and raphe release [73.3% (22/30)]. There was no 30-day mortality or stroke. At 10 years, the cumulative incidences of > moderate AI, severe AS, and reintervention were 7.6% (0-17.2%), 7.1% (0-19.7%), and 5.3% (0.3-22%), respectively. There was no mortality for the entire duration of the study period.

CONCLUSIONS

This series demonstrates excellent 10-year outcomes of maintaining commissural orientation in asymmetric BAV reimplantation procedures. However, further study with additional patients, longer follow-up, and direct comparison to symmetric reimplantation for similar BAV morphology is required.

摘要

背景

对于非常不对称的二叶式主动脉瓣(BAV)进行保留瓣膜的根部再植入术(VSRR)时,是应保留天然瓣叶交界方向的不对称性,还是应使其对称(180°-180°),目前仍存在争议。在此,我们介绍我们的方法,即保留天然的不对称性,并以210°-150°的方向进行瓣膜再植入。

方法

对2004年1月1日至2023年3月1日在单一机构接受VSRR的130例BAV患者进行回顾性研究。其中,37例进行了不对称再植入(210°-150°)。主要结局为中重度主动脉瓣关闭不全(AI)。次要结局包括重度主动脉瓣狭窄(AS)、再次干预和生存率。

结果

纳入的37例患者大多为男性[94.6%(35/37)],平均年龄46.3岁,合并症发生率较低。术前至少存在中重度AI的患者占40.5%(15/37)。本系列所有BAV均为Sievers 1型,平均瓣叶交界角为128.2°。81.1%(30/37)的患者需要进行瓣叶修复,最常见的是联合瓣叶的中央折叠[96.7%(29/30)]和嵴释放[73.3%(22/30)]。术后30天无死亡或卒中发生。10年时,中重度AI、重度AS和再次干预的累积发生率分别为7.6%(0-17.2%)、7.1%(0-19.7%)和5.3%(0.3-22%)。在整个研究期间无死亡病例。

结论

本系列研究表明,在不对称BAV再植入手术中维持瓣叶交界方向可获得优异的10年结局。然而,需要对更多患者进行进一步研究,延长随访时间,并与类似BAV形态的对称再植入进行直接比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f963/10405331/dc5c3e0e0d84/acs-12-04-318-f1.jpg

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