Freeman Hugh J
Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.
Gastroenterol Hepatol Bed Bench. 2023;16(2):145-150. doi: 10.22037/ghfbb.v16i2.2698.
Almost a half-century ago, an unusual and distinct form of colitis was first recognized, collagenous colitis, characterized by sub-epithelial trichrome-positive deposits having the ultrastructural features of collagen. Later, other reports documented more extensive collagenous dis-ease in these patients, sometimes in the stomach and small bowel, a close linkage with other forms of microscopic colitis and its association with celiac and other immune-mediated diseases. Moreover, emerging genetic methods permitted large studies of collagenous colitis to complement these intriguing clinical and pathological studies. Finally, recent and related studies have further demonstrated these immune-based forms of colitis, with new sprue-like intestinal diseases caused by novel medications, recently detected viral infections and vaccinations.
大约半个世纪前，一种不同寻常且独特的结肠炎形式——胶原性结肠炎首次被识别，其特征是上皮下三色染色阳性沉积物具有胶原的超微结构特征。后来，其他报告记录了这些患者中更广泛的胶原性疾病，有时累及胃和小肠，与其他形式的显微镜下结肠炎密切相关，并与乳糜泻和其他免疫介导的疾病有关。此外，新兴的基因方法使对胶原性结肠炎的大规模研究得以开展，以补充这些引人入胜的临床和病理研究。最后，最近的相关研究进一步证实了这些基于免疫的结肠炎形式，包括由新型药物引起的新的口炎性腹泻样肠道疾病、最近检测到的病毒感染和疫苗接种。
