Kanaev S V, Kolygin B A, Malinin A P, Chikrizov S I
Med Radiol (Mosk). 1986 Jul;31(7):14-8.
The results of treatment of I-II stage Hodgkin's disease in children aged 2-14 have been studied. 5-year survival in the group of patients (34 persons) subjected only to radiotherapy was 87.3% of which 63.4% had no recurrences. The radiotherapy is found to be an adequate method for treatment of Hodgkin's disease I-IIa stage in patients over 5 with histological types of lymphocytes prevalence and of nodular sclerosis. The volume dose of radiation does not effect the results significantly and may be limited to irradiation of local zones. When radiation is used in monotherapy there appeared factors worsening the prognosis of the disease. These are: age below 5, common symptoms and/or signs of biological activity of the process, histological mixed-cellular type or the type of lymphoid exhaustion. These factors do not affect significantly the prognosis of disease for children treated with chemoradiotherapy. In the presence of unfavourable factors only chemotherapy should be used. It does not result in the increase in 5-year survival but increases significantly (up to 90.9%) the frequency of recurrency-free interval.
对2至14岁儿童I-II期霍奇金病的治疗结果进行了研究。仅接受放射治疗的患者组(34人)的5年生存率为87.3%,其中63.4%无复发。已发现放射治疗是治疗5岁以上淋巴细胞为主型和结节硬化型组织学类型的I-IIa期霍奇金病患者的一种充分方法。放射剂量对结果无显著影响,可局限于局部区域照射。当放射治疗用于单一疗法时,出现了一些使疾病预后恶化的因素。这些因素包括:5岁以下、病程的常见症状和/或生物学活性体征、组织学混合细胞型或淋巴细胞耗竭型。这些因素对接受放化疗的儿童的疾病预后无显著影响。存在不利因素时应仅使用化疗。这不会导致5年生存率增加,但会显著提高(高达90.9%)无复发间期的频率。