Yoshizawa Hikari, Nishizawa Haruki, Ito Mayuko, Ohwaki Akiko, Sakabe Yoshiko, Sekiya Takao, Fujii Takuma, Kurahashi Hiroki
Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.
Fujita Med J. 2023 Aug;9(3):200-205. doi: 10.20407/fmj.2022-027. Epub 2022 Dec 27.
Nectin-4 is a cell adhesion molecule with vital functions at adherens and tight junctions. Cumulative evidence now indicates that the gene is overexpressed in a variety of cancers, and that the nectin-4 protein is both a disease marker and therapeutic target in a subset of these cancers. We previously demonstrated that is overexpressed in placenta during pre-eclamptic pregnancy, which is one of the most serious obstetric disorders.
Nectin-4 protein levels were measured in maternal sera from pregnant women with pre-eclampsia and its related disorder, unexplained fetal growth retardation.
Maternal serum concentrations of nectin-4 were significantly elevated in pre-eclamptic women compared with those with an uncomplicated normotensive pregnancy. However, no increase was observed in pregnancies with unexplained fetal growth retardation. Serum nectin-4 levels were higher in cases with early-onset pre-eclampsia that generally showed more severe clinical symptoms, but levels were not correlated to other clinical indicators of disease severity.
Nectin-4 is a potential new diagnostic and predictive biomarker for severe pre-eclampsia.
Nectin-4是一种细胞黏附分子，在黏附连接和紧密连接中发挥重要作用。目前越来越多的证据表明，该基因在多种癌症中过度表达，并且Nectin-4蛋白在这些癌症的一部分中既是疾病标志物又是治疗靶点。我们之前证明，在子痫前期妊娠期间，胎盘会过度表达，子痫前期是最严重的产科疾病之一。
检测子痫前期孕妇及其相关疾病（不明原因胎儿生长受限）孕妇血清中的Nectin-4蛋白水平。
与血压正常的未合并症孕妇相比，子痫前期孕妇血清中Nectin-4的浓度显著升高。然而，在不明原因胎儿生长受限的孕妇中未观察到升高。早发型子痫前期患者的血清Nectin-4水平较高，早发型子痫前期通常表现出更严重的临床症状，但该水平与疾病严重程度的其他临床指标无关。
Nectin-4是重度子痫前期潜在的新型诊断和预测生物标志物。
