Uddin Md Nasir, Figley Teresa D, Kornelsen Jennifer, Mazerolle Erin L, Helmick Carl A, O'Grady Christopher B, Pirzada Salina, Patel Ronak, Carter Sean, Wong Kaihim, Essig Marco R, Graff Lesley A, Bolton James M, Marriott James J, Bernstein Charles N, Fisk John D, Marrie Ruth Ann, Figley Chase R
Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Division of Diagnostic Imaging, Health Sciences Centre Winnipeg, Winnipeg, MB, Canada.
Front Neuroimaging. 2022 Aug 24;1:970385. doi: 10.3389/fnimg.2022.970385. eCollection 2022.
The Comorbidity and Cognition in Multiple Sclerosis (CCOMS) study represents a coordinated effort by a team of clinicians, neuropsychologists, and neuroimaging experts to investigate the neural basis of cognitive changes and their association with comorbidities among persons with multiple sclerosis (MS). The objectives are to determine the relationships among psychiatric (e.g., depression or anxiety) and vascular (e.g., diabetes, hypertension, etc.) comorbidities, cognitive performance, and MRI measures of brain structure and function, including changes over time. Because neuroimaging forms the basis for several investigations of specific neural correlates that will be reported in future publications, the goal of the current manuscript is to briefly review the CCOMS study design and baseline characteristics for participants enrolled in the three study cohorts (MS, psychiatric control, and healthy control), and provide a detailed description of the MRI hardware, neuroimaging acquisition parameters, and image processing pipelines for the volumetric, microstructural, functional, and perfusion MRI data.
多发性硬化症的共病与认知（CCOMS）研究是由一组临床医生、神经心理学家和神经影像学专家共同开展的一项协作研究，旨在探究认知变化的神经基础及其与多发性硬化症（MS）患者共病之间的关联。其目标是确定精神疾病（如抑郁症或焦虑症）和血管疾病（如糖尿病、高血压等）共病、认知表现以及脑结构和功能的MRI测量指标（包括随时间的变化）之间的关系。由于神经影像学是未来出版物中将要报道的几项特定神经关联研究的基础，因此本手稿的目的是简要回顾CCOMS研究设计以及三个研究队列（MS、精神疾病对照和健康对照）参与者的基线特征，并详细描述用于容积、微观结构、功能和灌注MRI数据的MRI硬件、神经影像学采集参数以及图像处理流程。
