Beijing Underproved Medical Technology Co., LTD., Beijing, China.
J Cosmet Dermatol. 2024 Jan;23(1):27-32. doi: 10.1111/jocd.15956. Epub 2023 Aug 9.
Enlarged facial pores are a common cosmetic concern of the skin, rather than a disease, and have not received much attention from dermatologists in recent years. Consequently, progress in understanding their pathogenesis has been limited, and current cosmetic solutions have limitations. Given that the complement system has regained interest as a key player in chronic inflammatory skin conditions, various mechanisms involving this system are being investigated.
We aimed to shed light on the mechanism underlying enlarged facial pores by examining the role of the complement system in skin.
We conducted a comprehensive literature search utilizing various academic databases including PubMed, Web of Science, and Google Scholar. Employing keywords such as "complement system," "inflammation," "facial pores," "enlarged," and "mechanisms," we compiled a selection of relevant studies. These studies provided a comprehensive understanding of the intricate mechanisms underlying the relationship between the "complement system" and "inflammation" within the context of facial pore enlargement.
Our findings suggest that inflammaging mediated by complement activation may be a critical player in the formation of enlarged facial pores. Specifically, overactivation of the complement system leading to the accumulation of complement fragments could be a major contributor to this process. Notably, the complement system in skin may be involved in a range of skin issues, including aging.
Modulating the complement system presents a promising avenue for future research in improving skin health. Further basic and clinical research is necessary to validate these findings, but we hope that this study can serve as a theoretical foundation for the development of targeted cosmetics.
毛孔粗大是一种常见的皮肤美容问题，而非疾病，但近年来皮肤科医生对其关注较少。因此，人们对其发病机制的认识进展有限，目前的美容解决方案也存在局限性。鉴于补体系统作为慢性炎症性皮肤病的关键因素重新受到关注，人们正在研究该系统涉及的各种机制。
通过研究补体系统在皮肤中的作用，阐明导致毛孔粗大的机制。
我们利用PubMed、Web of Science 和 Google Scholar 等各种学术数据库进行了全面的文献检索。使用“补体系统”“炎症”“毛孔”“粗大”和“机制”等关键词，我们选择了一些相关的研究。这些研究全面了解了“补体系统”和“炎症”与毛孔粗大之间关系的复杂机制。
我们的研究结果表明，补体激活介导的炎症衰老可能是形成粗大毛孔的关键因素。具体来说，补体系统的过度激活导致补体片段的积累可能是这一过程的主要原因。值得注意的是，皮肤中的补体系统可能与一系列皮肤问题有关，包括衰老。
调节补体系统为改善皮肤健康的未来研究提供了一个有前途的途径。有必要进行更多的基础和临床研究来验证这些发现，但我们希望这项研究可以为有针对性的化妆品的开发提供理论基础。
