Kim Juhyun, Ye Sanghyun, Jun Seung-Hyun, Kang Nae-Gyu
LG Household & Health Care (LG H&H) R&D Center, Seoul 07795, Republic of Korea.
Curr Issues Mol Biol. 2024 Aug 20;46(8):9122-9135. doi: 10.3390/cimb46080539.
Skin aging is a complex process with internal and external factors. Recent studies have suggested that enlargement and elongation of skin pores may be early signs of aging in addition to wrinkles and loss of elasticity. This study explores the potential of targeting the gene in keratinocytes to address these emerging concerns. Using siRNA knockdown, we demonstrated that modulates the production of inflammatory cytokines (interleukin (IL)-1β and IL-8). Furthermore, conditioned media experiments revealed that keratinocytes with high expression indirectly influence fibroblast extracellular matrix remodeling, potentially contributing to enlarged pores and wrinkle formation. Based on these findings, we explored a complex formulation containing four -modulating compounds. In vitro and in vivo experiments demonstrated the efficacy of the formulation in mitigating fine wrinkles and pore enlargement. This study highlights the significant implications of developing a more effective antiaging cosmetic formulation by targeting underlying inflammatory processes that drive skin aging.
皮肤老化是一个受内部和外部因素影响的复杂过程。最近的研究表明，除了皱纹和弹性丧失外，毛孔的增大和拉长可能是衰老的早期迹象。本研究探讨了靶向角质形成细胞中的该基因以解决这些新出现问题的潜力。通过小干扰RNA敲低，我们证明该基因调节炎性细胞因子（白细胞介素（IL）-1β和IL-8）的产生。此外，条件培养基实验表明，高表达该基因的角质形成细胞间接影响成纤维细胞外基质重塑，这可能导致毛孔增大和皱纹形成。基于这些发现，我们探索了一种含有四种调节化合物的复合配方。体外和体内实验证明了该配方在减轻细纹和毛孔增大方面的功效。本研究强调了通过靶向驱动皮肤老化的潜在炎症过程来开发更有效的抗老化化妆品配方的重大意义。
