Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Cosmet Dermatol. 2021 Nov;20(11):3467-3474. doi: 10.1111/jocd.14360. Epub 2021 Aug 5.
Enlarged facial pores are a common cosmetic complaint in practice. Microfocused ultrasound with visualization (MFU-V) and low-degree crosslinked hyaluronic acid filler (L-HA) injection has recently become a popular procedure for skin rejuvenation. The effectiveness of the combined MFU-V and L-HA injection in the treatment of enlarged pores has not been evaluated.
To compare the efficacy of MFU-V monotherapy (single technique) and MFU-V combined with L-HA injection (combined technique) for the treatment of enlarged facial pores in Asians.
We conducted a randomized, single-blinded, split-face study on participants with enlarged facial pores. Each side of the face was randomly assigned to treatment with one session of single technique or combined technique. Pore volume was objectively measured by an Antera 3D system. Subjective assessment was evaluated by one-blinded physician using a pore grading score (0-4). Patients rated the improvement in terms of satisfaction using the visual analog scale (VAS, 0-10).
Forty-six participants completed the study. The mean pore volume of both sides declined with statistical significance at every visit compared to baseline, with the lowest mean at 4 months post-treatment. The combined technique showed a lower mean pore volume than single technique throughout the follow-ups. Physician's subjective evaluation showed no statistically significant difference between the two techniques. The patient satisfaction score showed a similar trend to the mean pore volume, with a statistically significant difference at 4 and 6 months post-treatment.
Both techniques are effectively minimize enlarged facial pores. The combined technique resulted in more patient satisfaction.
毛孔粗大是临床上常见的美容诉求。微聚焦超声可视化（MFU-V）联合低浓度交联透明质酸填充剂（L-HA）注射最近已成为一种颇受欢迎的皮肤年轻化治疗手段。但 MFU-V 联合 L-HA 注射治疗毛孔粗大的疗效尚未得到评估。
比较 MFU-V 单疗法（单一技术）和 MFU-V 联合 L-HA 注射（联合技术）治疗亚洲人面部毛孔粗大的疗效。
我们对存在面部毛孔粗大的参与者进行了一项随机、单盲、自身对照的分面研究。每侧面部随机接受单一技术或联合技术治疗 1 次。采用 Antera 3D 系统客观测量毛孔体积。采用盲法医生的毛孔分级评分（0-4 分）对主观评估进行评价。患者采用视觉模拟评分（VAS，0-10 分）评价改善程度的满意度。
46 名参与者完成了研究。与基线相比，两侧的平均毛孔体积在每次随访时均有统计学意义的下降，治疗后 4 个月最低。在整个随访过程中，联合技术的平均毛孔体积均低于单一技术。两种技术的医生主观评价无统计学差异。患者满意度评分与平均毛孔体积呈相似趋势，治疗后 4 个月和 6 个月时差异有统计学意义。
两种技术均能有效缩小面部毛孔。联合技术能带来更高的患者满意度。
