早产儿视网膜病变：发病年龄
Retinopathy of prematurity: age at onset.
作者信息
Fielder A R, Ng Y K, Levene M I
出版信息
Arch Dis Child. 1986 Aug;61(8):774-8. doi: 10.1136/adc.61.8.774.
The age at which retinopathy of prematurity was first seen was determined in 143 infants. In all, the initial ophthalmological examination was normal. Birth weights varied from 630 to 2700 g and gestational ages from 24.5 to 40.0 weeks. The median postnatal age at which acute retinopathy of prematurity was first seen was 51 and 40 days for those less than 28 and greater than or equal to 28 weeks' gestational age, respectively, and this difference is highly significant. Similar results were obtained when infants were grouped according to birth weight less than 1000 or greater than or equal to 1000 g. Using postmenstrual age as the variable, the first signs of retinopathy of prematurity were seen over a fairly narrow age range and 86% of infants developed retinopathy between 32.5 and 38.5 weeks of age. These findings suggest that the age (but not the occurrence or severity) at which retinopathy of prematurity is first seen is controlled predominantly by stage of development rather than neonatal events.
在143名婴儿中确定了首次发现早产儿视网膜病变的年龄。总体而言，初次眼科检查结果正常。出生体重从630克到2700克不等，胎龄从24.5周到40.0周不等。对于胎龄小于28周和大于或等于28周的婴儿，首次发现急性早产儿视网膜病变的出生后中位年龄分别为51天和40天，这种差异非常显著。当根据出生体重小于1000克或大于或等于1000克对婴儿进行分组时，也得到了类似的结果。以月经后年龄作为变量，早产儿视网膜病变的最初迹象出现在相当狭窄的年龄范围内，86%的婴儿在32.5至38.5周龄时出现视网膜病变。这些发现表明，首次发现早产儿视网膜病变的年龄（而非其发生或严重程度）主要受发育阶段而非新生儿事件控制。
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