State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Technology University, Nanjing, 210009, Jiangsu Province, People's Republic of China.
Bioprocess Biosyst Eng. 2023 Dec;46(12):1695-1709. doi: 10.1007/s00449-023-02918-w. Epub 2023 Aug 9.
Vitamin E (VE) is a natural antioxidant which is widely used in the food fields, while the shortcomings of easy oxidative inactivation and poor water solubility limit its application. Vitamin E esters' (VEEs) derivatives, such as vitamin E acetate (VEA), are more stable and easier to be absorbed while have similar biological activities and physiological functions compared with VE. In this systematic review, the digestion, absorption and physiological function of VEEs were summarized. To promote their further industrial applications, the synthesis strategies of VEEs were also summarized in-depth. In particular, as a new generation of green solvents, ionic liquids (ILs) have been widely used in enzymatic reactions due to the stabilization and activation of enzymes. Their applications in enzymatic synthesis of VEEs were summarized and discussed. Finally, several future perspectives for developing more efficiency strategies of VEEs synthesis, such as enzyme engineering and design of novel ILs, were also discussed.
维生素 E（VE）是一种天然抗氧化剂，广泛应用于食品领域，但其易氧化失活和水溶性差的缺点限制了其应用。VE 的酯类（VEEs）衍生物，如醋酸维生素 E（VEA），则更加稳定，且更容易被吸收，同时具有与 VE 相似的生物学活性和生理功能。在本系统评价中，总结了 VEEs 的消化、吸收和生理功能。为了促进其进一步的工业应用，还深入总结了 VEEs 的合成策略。特别是，作为新一代绿色溶剂，离子液体（ILs）由于对酶的稳定和激活作用，已广泛应用于酶反应中。对其在 VEEs 酶合成中的应用进行了总结和讨论。最后，还讨论了几种未来的发展方向，如酶工程和新型 ILs 的设计，以开发更高效的 VEEs 合成策略。
