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激光与经闭孔吊带治疗压力性尿失禁的比较及超重在治疗中的作用:一项前瞻性观察研究。

Comparison between laser and transobturator tape therapy in the treatment of stress urinary incontinence and role of overweight in treatment: a prospective observational study.

机构信息

Department of Nutrition and Dietetics, Faculty of Health Sciences, Dicle University, Diyarbakır, Turkey.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkey.

出版信息

Int Urogynecol J. 2023 Dec;34(12):2901-2908. doi: 10.1007/s00192-023-05625-y. Epub 2023 Aug 9.

DOI:10.1007/s00192-023-05625-y
PMID:37555966
Abstract

INTRODUCTION AND HYPOTHESIS

Stress urinary incontinence (SUI) is treated with transobturator tape (TOT) sling procedures, but problems arise with artificial mesh in certain instances. Hence, non-invasive laser therapy may be useful under such circumstances. The current study was aimed at comparing the effects of these two treatments and at checking their applicability in various body mass index (BMI) groups.

METHODS

Seventy-nine patients, who were clinically diagnosed with SUI, were divided into two groups, those who preferred TOT and those who preferred the transvaginal fractional micro-ablative CO laser system. The SUI symptoms and International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) scores of the patients were determined before and at the 12th month after the treatment. General linear model, Stuart-Maxwell, and Bonferroni correction for pairwise comparison analyses were performed to compare the efficacy of the treatment type.

RESULTS

The ICIQ-SF score decreased by 56.8% for laser therapy and 43.5% for TOT therapy (mean ± SE = 5.97 ± 0.16 and 5.09 ± 0.14 respectively). Laser therapy had a better effect on ICIQ-SF than TOT therapy (η2p: 0.176, p < 0.001). Regardless of the types of treatment, the ICIQ-SF scores of healthy-weight participants decreased more than those of overweight participants (η2p:0.050, p = 0.045). In the TOT group, healthy-weight participants were more than twice as likely to recover fully from SUI symptoms as overweight participants, 1 year after the treatment. In the laser group, the majority of healthy-weight participants (88.8%) did not report any SUI symptoms after the treatment.

CONCLUSIONS

The efficacy of laser therapy for urinary incontinence was confirmed. Furthermore, it was observed that being overweight may be a risk factor for the failure of laser therapy.

摘要

介绍和假设

压力性尿失禁(SUI)采用经闭孔吊带(TOT)手术治疗,但在某些情况下,人造网会出现问题。因此,在这种情况下,非侵入性激光治疗可能是有用的。本研究旨在比较这两种治疗方法的效果,并检查它们在不同身体质量指数(BMI)组中的适用性。

方法

79 名临床诊断为 SUI 的患者被分为两组,一组倾向于 TOT,另一组倾向于经阴道分数微磨蚀 CO2 激光系统。在治疗前和治疗后 12 个月,对患者的 SUI 症状和国际尿失禁咨询问卷简表(ICIQ-SF)评分进行了测定。采用一般线性模型、斯图尔特-马克斯韦尔和 Bonferroni 校正进行配对比较分析,以比较治疗类型的疗效。

结果

激光治疗组 ICIQ-SF 评分下降 56.8%,TOT 治疗组下降 43.5%(平均值±标准误差分别为 5.97±0.16 和 5.09±0.14)。激光治疗组的 ICIQ-SF 评分优于 TOT 治疗组(η2p:0.176,p<0.001)。无论治疗类型如何,健康体重参与者的 ICIQ-SF 评分下降幅度均大于超重参与者(η2p:0.050,p=0.045)。在 TOT 组中,治疗 1 年后,健康体重参与者完全恢复 SUI 症状的可能性是超重参与者的两倍多。在激光组中,大多数健康体重参与者(88.8%)在治疗后没有报告任何 SUI 症状。

结论

证实了激光治疗尿失禁的疗效。此外,还观察到超重可能是激光治疗失败的一个风险因素。

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本文引用的文献

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Clinical Guidelines for Female Lower Urinary Tract Symptoms (second edition).女性下尿路症状临床指南(第二版)
Int J Urol. 2021 May;28(5):474-492. doi: 10.1111/iju.14492. Epub 2021 Mar 1.
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Obesity as a risk factor for poor outcomes after sling surgery in women with stress urinary incontinence: A systematic review and meta-analysis.肥胖作为女性压力性尿失禁吊带手术后结局不佳的危险因素:系统评价和荟萃分析。
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Er:YAG laser treatment of urinary incontinence after failed TOT/TVT procedures.
铒激光治疗经闭孔无张力尿道中段吊带术/经阴道无张力尿道中段吊带术失败后的尿失禁
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Comparison between erbium-doped yttrium aluminum garnet laser therapy and sling procedures in the treatment of stress and mixed urinary incontinence.铒激光与吊带手术治疗压力性及混合性尿失禁的比较。
World J Urol. 2019 May;37(5):885-889. doi: 10.1007/s00345-018-2445-x. Epub 2018 Aug 16.
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The Efficiency and Safety of Tension-Free Vaginal Tape (TVT) Abbrevo Procedure Versus TVT Exact in the Normal Weight and Overweight Patients Affected by Stress Urinary Incontinence.无张力阴道吊带术(TVT)Abbrevo术式与TVT Exact术式在体重正常和超重的压力性尿失禁患者中的有效性和安全性比较
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High body mass and kidney dysfunction relate to worse nerve function, even in adults without neuropathy.即使在没有神经病变的成年人中,高体重和肾功能不全也与较差的神经功能有关。
J Peripher Nerv Syst. 2017 Jun;22(2):112-120. doi: 10.1111/jns.12211.
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Role of intrinsic sphincter deficiency with and without urethral hypomobility on the outcome of tape insertion.伴有或不伴有尿道活动度降低的固有括约肌功能不全在吊带置入结果中的作用。
Neurourol Urodyn. 2017 Sep;36(7):1910-1916. doi: 10.1002/nau.23211. Epub 2017 Jan 31.
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