Suppr超能文献

COVID-19大流行期间过滤式面罩呼吸器对纳米颗粒的过滤性能检测

Examination of Nanoparticle Filtration by Filtering Facepiece Respirators During the COVID-19 Pandemic.

作者信息

Hao Junli, Passos de Oliveira Santos Rachel, Rutledge Gregory C

机构信息

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Department of Biosystems Engineering, University of São Paulo, São Paulo 13630-000, Brazil.

出版信息

ACS Appl Nano Mater. 2021 Apr 6;4(4):3675-3685. doi: 10.1021/acsanm.1c00139. eCollection 2021 Apr 23.

Abstract

The onset of the COVID-19 pandemic in spring 2020 resulted in a spike in the demand for face masks and respirators. Due to their effectiveness at filtering aerosols that could potentially contain viruses, the N95-type filtering facepiece respirators (FFRs) are frequently used by healthcare workers and first responders. However, due to a shortage of domestic N95 FFRs in the US at the beginning of the pandemic, internationally produced respirators were imported and deployed under an Emergency Use Authorization by the Food and Drug Administration. Due to concerns raised at the time, there was an urgent need to verify their effectiveness and usability. In this study, we summarize our characterization of the nanoparticulate filtration performances of 136 such respirators, measured between April 1 and June 30, 2020. Our results indicate that about 42% of the respirators showed filtration efficiencies better than 90% (≤10% penetration), but only 17% performed better than 95% (≤5% penetration). On the other hand, about 35% showed filtration efficiencies below 80% (≥20% penetration). A representative subset of devices was analyzed for the origin of such variations in filtration performance. We found that filtration efficiency increased with the level of electrostatic charge on the FFRs and that the poor performance of the internationally sourced FFRs could be traced to a lack of electrostatic filtration mechanisms. Furthermore, electrostatics shifted the particle size at which aerosol penetration through the FFR was maximal from around 200 nm to less than 100 nm for the highest-performing FFRs, a size range that largely goes undetected in standardized tests.

摘要

2020年春季新冠疫情的爆发导致口罩和呼吸器的需求激增。由于N95型过滤式面罩呼吸器(FFR)在过滤可能含有病毒的气溶胶方面具有有效性,医护人员和急救人员经常使用。然而,在疫情初期,由于美国国内N95 FFR短缺,进口了国际生产的呼吸器,并根据美国食品药品监督管理局的紧急使用授权进行部署。由于当时人们提出的担忧,迫切需要验证它们的有效性和可用性。在本研究中,我们总结了2020年4月1日至6月30日期间对136个此类呼吸器的纳米颗粒过滤性能的表征。我们的结果表明,约42%的呼吸器过滤效率高于90%(穿透率≤10%),但只有17%的呼吸器性能优于95%(穿透率≤5%)。另一方面,约35%的呼吸器过滤效率低于80%(穿透率≥20%)。对一组具有代表性的设备进行了分析,以探究过滤性能存在此类差异的原因。我们发现,过滤效率随着FFR上静电荷水平的提高而增加,并且国际采购的FFR性能不佳可归因于缺乏静电过滤机制。此外,对于性能最佳的FFR,静电作用将气溶胶穿透FFR的最大粒径从约200纳米转移至小于100纳米,这一粒径范围在标准化测试中基本未被检测到。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验