Department of Gastroenterology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, China.
J Biophotonics. 2023 Dec;16(12):e202300193. doi: 10.1002/jbio.202300193. Epub 2023 Aug 24.
Colorectal cancer is a prevalent malignancy globally, often linked to chronic colitis. Terahertz technology, with its noninvasive and fingerprint spectroscopic properties, holds promise in disease diagnosis. This study aimed to explore terahertz technology's application in colitis-associated cancer using a mouse model. Mouse colorectal tissues were transformed into paraffin-embedded blocks for histopathological analysis using HE staining. Terahertz transmission spectroscopy was performed on the tissue blocks. By comparing terahertz absorption differences, specific frequency bands were identified as optimal for distinguishing cancerous and normal tissues. The study revealed that terahertz spectroscopy effectively differentiates colitis-related cancers from normal tissues. Remarkably, 1.8 THz emerged as a potential optimal frequency for diagnosing colorectal cancer in mice. This suggests the potential for rapid histopathological diagnosis of colorectal cancer using terahertz technology.
结直肠癌是一种全球普遍存在的恶性肿瘤，常与慢性结肠炎有关。太赫兹技术具有非侵入性和指纹光谱特性，有望应用于疾病诊断。本研究旨在利用小鼠模型探讨太赫兹技术在结肠炎相关癌症中的应用。将小鼠结直肠组织转化为石蜡包埋块，通过 HE 染色进行组织病理学分析。对组织块进行太赫兹透射光谱分析。通过比较太赫兹吸收差异，确定了特定的频带作为区分癌组织和正常组织的最佳频带。研究表明，太赫兹光谱技术可有效区分结肠炎相关癌症与正常组织。值得注意的是，1.8 THz 成为诊断小鼠结直肠癌的潜在最佳频率。这表明太赫兹技术有望用于快速进行结直肠癌的组织病理学诊断。
