• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump.

作者信息

Vaidya Akhil B

机构信息

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129.

出版信息

Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2310870120. doi: 10.1073/pnas.2310870120. Epub 2023 Aug 9.

DOI:10.1073/pnas.2310870120
PMID:37556486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10450399/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d374/10450399/561d82c9e956/pnas.2310870120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d374/10450399/561d82c9e956/pnas.2310870120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d374/10450399/561d82c9e956/pnas.2310870120fig01.jpg

相似文献

1
Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump.引发疟原虫的消化不良:质子泵的基因操作
Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2310870120. doi: 10.1073/pnas.2310870120. Epub 2023 Aug 9.
2
Artemisinin-Resistant and HRP-Negative Malaria Parasites in Africa.非洲的青蒿素耐药且血蓝蛋白阴性疟原虫
N Engl J Med. 2023 Sep 28;389(13):1162-1164. doi: 10.1056/NEJMp2309142.
3
Malaria Prophylaxis Failure with Doxycycline, Central African Republic, 2014.2014年,中非共和国多西环素预防疟疾失败
Emerg Infect Dis. 2015 Aug;21(8):1485-6. doi: 10.3201/eid2108.150524.
4
Antimalarials Targeting the Malaria Parasite Cation ATPase ATP4 (PfATP4).靶向疟原虫阳离子ATP酶ATP4(PfATP4)的抗疟药。
Curr Top Med Chem. 2023;23(3):214-226. doi: 10.2174/1568026623666221121154354.
5
Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.疟疾和巴贝斯虫病血液期寄生虫之间广泛的共同化学敏感性。
Antimicrob Agents Chemother. 2016 Jul 22;60(8):5059-63. doi: 10.1128/AAC.00928-16. Print 2016 Aug.
6
Malaria pharmacogenomics: return to the future.疟疾药物基因组学:回归未来。
Pharmacogenomics. 2013 May;14(7):707-10. doi: 10.2217/pgs.13.41.
7
Unusual blood smear with multiple stages of Plasmodium falciparum infection and intraleukocytic malaria pigments in an expatriate with severe malaria and delayed clearance of parasites.一名患有严重疟疾且寄生虫清除延迟的外籍人士的异常血涂片,显示有多个恶性疟原虫感染阶段及白细胞内疟色素。
J Travel Med. 2023 May 18;30(3). doi: 10.1093/jtm/taad012.
8
Erythroid cells and malaria parasites: it's a match!红细胞和疟原虫:绝配!
Curr Opin Hematol. 2021 May 1;28(3):158-163. doi: 10.1097/MOH.0000000000000641.
9
Prevalence of chloroquine resistance alleles among Plasmodium falciparum parasites in countries affected by malaria disease since change of treatment policy: a systematic review protocol.疟疾治疗政策改变后受影响国家间间日疟原虫寄生虫中氯喹耐药等位基因的流行情况:系统评价方案。
Syst Rev. 2018 Jul 27;7(1):108. doi: 10.1186/s13643-018-0780-z.
10
Repurposing Drugs to Fight Hepatic Malaria Parasites.重新利用药物来对抗肝疟疾寄生虫。
Molecules. 2020 Jul 28;25(15):3409. doi: 10.3390/molecules25153409.

本文引用的文献

1
The role of V-ATPase in vacuolar physiology and antimalarial drug uptake.V-ATPase 在液泡生理学和抗疟药物摄取中的作用。
Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2306420120. doi: 10.1073/pnas.2306420120. Epub 2023 Jul 18.
2
The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals.V-ATP酶a亚基的胞质N端结构域是一个受多种信号作用的调控中心。
Front Mol Biosci. 2023 Jun 16;10:1168680. doi: 10.3389/fmolb.2023.1168680. eCollection 2023.
3
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
低剂量二甲双胍通过 PEN2 靶向溶酶体 AMPK 通路。
Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23.
4
The H-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.H-ATP 酶(V-ATP 酶):在健康和疾病中的质子泵到信号复合物。
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C392-C414. doi: 10.1152/ajpcell.00442.2020. Epub 2020 Dec 16.
5
Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.V-ATP酶组装的调控以及V-ATP酶在肿瘤细胞侵袭中的功能
Biochim Biophys Acta. 2016 Aug;1857(8):1213-1218. doi: 10.1016/j.bbabio.2016.02.010. Epub 2016 Feb 22.
6
Targeting reversible disassembly as a mechanism of controlling V-ATPase activity.靶向可逆组装作为控制 V-ATPase 活性的机制。
Curr Protein Pept Sci. 2012 Mar;13(2):117-23. doi: 10.2174/138920312800493142.
7
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.液泡型ATP酶:生理与病理生理学中的旋转质子泵
Nat Rev Mol Cell Biol. 2007 Nov;8(11):917-29. doi: 10.1038/nrm2272.
8
Hemoglobin degradation.血红蛋白降解
Curr Top Microbiol Immunol. 2005;295:275-91. doi: 10.1007/3-540-29088-5_11.
9
A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte.一种由疟原虫编码的液泡H(+) -ATP酶定位于宿主红细胞。
J Biol Chem. 2005 Nov 4;280(44):36841-7. doi: 10.1074/jbc.M507727200. Epub 2005 Aug 31.
10
Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.疟原虫消化液泡通过一种H⁺-ATP酶和一种H⁺-焦磷酸酶进行酸化。
J Biol Chem. 2003 Feb 21;278(8):5605-12. doi: 10.1074/jbc.M208648200. Epub 2002 Nov 8.