Adrian T E, Sagor G R, Savage A P, Bacarese-Hamilton A J, Hall G M, Bloom S R
J Clin Endocrinol Metab. 1986 Oct;63(4):803-7. doi: 10.1210/jcem-63-4-803.
Peptide YY (PYY) is a 36 amino acid peptide produced by mucosal endocrine cells of the ileum and colon which inhibits acid secretion and intestinal transit in man. To assess its effects on metabolites and digestive hormones PYY was infused into 18 fasting normal subjects at three dose levels (0.06, 0.19, and 0.57 pmol kg-1 min-1), each for a period of 1 h. During the infusions mean plasma PYY levels increased by 8, 25, and 73 pmol/liter, respectively. The mean disappearance half-time on stopping the infusions was 9.2 +/- 0.4 (SEM) min. The mean MCR was 7.3 +/- 0.7 ml kg-1 min-1 and the apparent volume of distribution was calculated to be 94 +/- 9 ml kg-1. During the highest dose infusion there was a significant increase in both systolic and diastolic blood pressure, of 8.6 +/- 3.7 mmHg (P less than 0.05) and 10.9 +/- 3.0 mmHg (P less than 0.01), respectively. PYY caused a significant 50% reduction in plasma pancreatic polypeptide concentrations (P less than 0.05) and a 55% reduction in circulating motilin levels (P less than 0.05). PYY had no significant effect on circulating concentrations of insulin, glucagon, gastrin, gastric inhibitory peptide, neurotensin, enteroglucagon, or vasoactive intestinal peptide. PYY also had no significant effect on circulating concentrations of glucose, lactate, glycerol, or nonesterified fatty acids. This recently discovered human intestinal hormonal peptide thus has significant effects both on gastrointestinal hormones (motilin and pancreatic polypeptide) and blood pressure in man, but appears not to influence glucose or lipid metabolism.
肽YY（PYY）是一种由回肠和结肠的黏膜内分泌细胞产生的36个氨基酸的肽，它可抑制人体胃酸分泌和肠道蠕动。为评估其对代谢物和消化激素的影响，将PYY以三种剂量水平（0.06、0.19和0.57 pmol·kg⁻¹·min⁻¹）输注给18名空腹的正常受试者，每个剂量水平持续1小时。输注期间，血浆PYY平均水平分别升高了8、25和73 pmol/升。停止输注后的平均消失半衰期为9.2±0.4（SEM）分钟。平均代谢清除率为7.3±0.7 ml·kg⁻¹·min⁻¹，计算得出的表观分布容积为94±9 ml·kg⁻¹。在最高剂量输注期间，收缩压和舒张压均显著升高，分别升高了8.6±3.7 mmHg（P<0.05）和10.9±3.0 mmHg（P<0.01）。PYY使血浆胰多肽浓度显著降低50%（P<0.05），使循环中胃动素水平降低55%（P<0.05）。PYY对胰岛素、胰高血糖素、胃泌素、胃抑制肽、神经降压素、肠高血糖素或血管活性肠肽的循环浓度无显著影响。PYY对葡萄糖、乳酸、甘油或非酯化脂肪酸的循环浓度也无显著影响。因此，这种最近发现的人体肠道激素肽对人体胃肠道激素（胃动素和胰多肽）和血压有显著影响，但似乎不影响葡萄糖或脂质代谢。
