Blackburn A M, Fletcher D R, Adrian T E, Bloom S R
J Clin Endocrinol Metab. 1980 Dec;51(6):1257-61. doi: 10.1210/jcem-51-6-1257.
Synthetic neurotensin was infused into five healthy subjects at a mean dose of 2.3 pmol/kg . min for 30 min, producing a rise in plasma neurotensin concentrations, measured by RIA of 104 +/- 10 (mean +/- SEM) pmol/liter. The mean disappearance half-time on stopping the infusion was 3.8 +/- 0.2 min. The MCR was 16 +/- 1 ml/kg . min, and the apparent space of distribution was 88 +/- 6 ml/kg. During the neurotensin infusions, plasma pancreatic polypeptide rose by 145 +/- 54 pmol/liter. In contrast to results in experimental animals, there was no significant change in the pulse or blood pressure of the subjects or any significant change in blood glucose or plasma concentrations of insulin, glucagon, gastric inhibitory peptide, gastrin, motilin, or vasoactive intestinal peptide. Similarly, there was no change in plasma concentrations of TSH, GH, PRL, LH, and FSH.
向5名健康受试者输注合成神经降压素，平均剂量为2.3皮摩尔/千克·分钟，持续30分钟，通过放射免疫分析法（RIA）测得血浆神经降压素浓度升高至104±10（均值±标准误）皮摩尔/升。停止输注后，平均消失半衰期为3.8±0.2分钟。代谢清除率（MCR）为16±1毫升/千克·分钟，表观分布容积为88±6毫升/千克。在输注神经降压素期间，血浆胰多肽升高了145±54皮摩尔/升。与实验动物的结果相反，受试者的脉搏或血压没有显著变化，血糖或胰岛素、胰高血糖素、胃抑制肽、胃泌素、胃动素或血管活性肠肽的血浆浓度也没有显著变化。同样，促甲状腺激素（TSH）、生长激素（GH）、催乳素（PRL）、黄体生成素（LH）和卵泡刺激素（FSH）的血浆浓度也没有变化。
