Ghatei M A, Jung R T, Stevenson J C, Hillyard C J, Adrian T E, Lee Y C, Christofides N D, Sarson D L, Mashiter K, MacIntyre I, Bloom S R
J Clin Endocrinol Metab. 1982 May;54(5):980-5. doi: 10.1210/jcem-54-5-980.
Bombesin, a peptide with widespread biological actions, has been demonstrated in human tissues by immunological methods. To investigate its effect in man, synthetic bombesin was infused at low doses in six male volunteers. Bombesin at 2.4 pmol kg-1 min-1 produced significant rises in plasma insulin, glucagon, pancreatic polypeptide, gastrin, cholecystokinin, motilin, glucose-dependent insulinotropic polypeptide, neurotensin, enteroglucagon, vasoactive intestinal polypeptide, and serum calcium. In contrast, bombesin caused a profound fall in parathyroid hormone levels and reduced plasma glucose concentrations. A late rise in plasma calcitonin was also observed. Bombesin had no significant effect on the pituitary hormones, TSH, GH, PRL, or cortisol. No hormonal changes or alterations in calcium were noted during saline infusions. Bombesin has a marked stimulatory effect on gastrointestinal hormones, which is unique and opposite to the effect of somatostatin, a potent inhibitor of gut hormone release. Bombesin also influences calcium-regulating hormones, either directly or through its action on gut hormones. The bombesin concentrations achieved with the dosages used were low enough to indicate a possible physiological role for the endogenous peptide.
蛙皮素是一种具有广泛生物学作用的肽，已通过免疫学方法在人体组织中得到证实。为了研究其对人体的作用，对6名男性志愿者以低剂量输注合成蛙皮素。以2.4 pmol kg-1 min-1的剂量输注蛙皮素会使血浆胰岛素、胰高血糖素、胰多肽、胃泌素、胆囊收缩素、胃动素、葡萄糖依赖性促胰岛素多肽、神经降压素、肠高血糖素、血管活性肠多肽和血清钙显著升高。相比之下，蛙皮素会使甲状旁腺激素水平大幅下降，并降低血浆葡萄糖浓度。还观察到血浆降钙素在后期升高。蛙皮素对垂体激素促甲状腺激素（TSH）、生长激素（GH）、催乳素（PRL）或皮质醇没有显著影响。输注生理盐水期间未观察到激素变化或钙的改变。蛙皮素对胃肠激素有显著的刺激作用，这是独特的，且与生长抑素（一种强力的肠道激素释放抑制剂）的作用相反。蛙皮素还直接或通过其对胃肠激素的作用影响钙调节激素。所用剂量达到的蛙皮素浓度足够低，表明内源性肽可能具有生理作用。
