人类T细胞受体β链可变区基因的序列与多样性
Sequences and diversity of human T cell receptor beta chain variable region genes.
作者信息
Kimura N, Toyonaga B, Yoshikai Y, Triebel F, Debre P, Minden M D, Mak T W
出版信息
J Exp Med. 1986 Sep 1;164(3):739-50. doi: 10.1084/jem.164.3.739.
Abstract
The nucleotide sequences of 22 human T cell antigen receptor (TcR) beta chain variable region genes isolated from various T lymphocytes have been analyzed. Of the 19 variable gene segment (V beta)-containing sequences, 17 were unique. The V beta gene segments were grouped into 11 families. Comparisons were made with the data of Concannon et al. to unify the nomenclature. The data is consistent with a total V beta gene segment repertoire with a most probable value of 38 members and an upper bound of 104 members at the 95% confidence level. Southern blot data of germline DNA using selected TcR V beta cDNAs as probes support this estimate. The human repertoire is approximately three to four times greater than that reported for the mouse. Explanations for this discrepancy are proposed.
摘要
对从各种T淋巴细胞中分离出的22个人类T细胞抗原受体（TcR）β链可变区基因的核苷酸序列进行了分析。在19个含有可变基因片段（Vβ）的序列中，17个是独特的。Vβ基因片段被分为11个家族。与康坎农等人的数据进行了比较，以统一命名法。数据与一个总Vβ基因片段库一致，在95%置信水平下，最可能的值为38个成员，上限为104个成员。使用选定的TcR Vβ cDNA作为探针的种系DNA的Southern印迹数据支持这一估计。人类的基因库大约是小鼠报道的基因库的三到四倍。对这种差异提出了解释。
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