人类T细胞受体β链基因转录本的序列与表达
Sequence and expression of transcripts of the human T-cell receptor beta-chain genes.
作者信息
Yoshikai Y, Anatoniou D, Clark S P, Yanagi Y, Sangster R, Van den Elsen P, Terhorst C, Mak T W
出版信息
Nature. 1984;312(5994):521-4. doi: 10.1038/312521a0.
DOI:10.1038/312521a0
PMID:6334237
Abstract
T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor beta-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.
摘要
T淋巴细胞可从T细胞抗原受体β链的第一个或第二个恒定区产生信使核糖核酸。一种编码成熟蛋白的1.3千碱基（kb）转录本包含V、J以及两个C区序列之一，但并不总是包含D序列。一种主要在未成熟T细胞中发现的1.0 kb信使核糖核酸不包含V序列，它可能源于从未重排的J元件上游起始的转录。
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