de Gaetano G, Carriero M R, Cerletti C, Mussoni L
Biochem Pharmacol. 1986 Sep 15;35(18):3147-50. doi: 10.1016/0006-2952(86)90400-4.
Interest in the antithrombotic potential of low-dose aspirin is based on its ability to inhibit thromboxane (Tx)A2-related platelet function with concomitant sparing of vascular prostacyclin (PGI2) production. The aim of this study was to investigate the effect of low-dose aspirin (20 mg daily for 7 days) on the increase in fibrinolytic activity in healthy volunteers after venous occlusion. We also tested the effect of high-dose aspirin (650 mg X 2), of salicylate (569 mg X 2) and of indobufen (200 mg X 2), a new cyclo-oxygenase inhibitor unrelated to salicylates. Low-dose aspirin reduced serum TxB2 generation by about 90% and suppressed arachidonate-induced platelet aggregation. In contrast, fibrinolytic activity, measured by the euglobulin lysis area and the euglobulin lysis time, was not significantly affected. Both high-dose aspirin and indobufen significantly inhibited TxB2 generation and the rise in fibrinolytic activity induced by venous occlusion, without affecting the pre-occlusion values. Salicylate did not significantly affect any parameter studied. Besides offering a favorable solution to the "aspirin dilemma" related to the TxA2/PGI2 balance, low-dose aspirin might leave intact the fibrinolytic capacity of the vessel wall.
对低剂量阿司匹林抗血栓形成潜力的关注基于其抑制血栓素（Tx）A2相关血小板功能的能力，同时保留血管前列环素（PGI2）的生成。本研究的目的是调查低剂量阿司匹林（每日20毫克，共7天）对健康志愿者静脉阻塞后纤溶活性增加的影响。我们还测试了高剂量阿司匹林（650毫克×2）、水杨酸盐（569毫克×2）和吲哚布芬（200毫克×2）的效果，吲哚布芬是一种与水杨酸盐无关的新型环氧化酶抑制剂。低剂量阿司匹林使血清TxB2生成减少约90%，并抑制花生四烯酸诱导的血小板聚集。相比之下，通过优球蛋白溶解面积和优球蛋白溶解时间测量的纤溶活性没有受到显著影响。高剂量阿司匹林和吲哚布芬均显著抑制TxB2生成以及静脉阻塞诱导的纤溶活性升高，且不影响阻塞前的值。水杨酸盐对所研究的任何参数均无显著影响。除了为与TxA2/PGI2平衡相关的“阿司匹林困境”提供一个有利的解决方案外，低剂量阿司匹林可能使血管壁的纤溶能力保持完整。
