青少年慢性关节炎中纤维蛋白溶解活性降低。
Decreased fibrinolytic activity in juvenile chronic arthritis.
作者信息
Mussoni L, Pintucci G, Romano G, De Benedetti F, Massa M, Martini A
机构信息
Istituto di Ricerche, Farmacologiche Mario Negri, Milan, Italy.
出版信息
Ann Rheum Dis. 1990 Dec;49(12):973-5. doi: 10.1136/ard.49.12.973.
Abstract
The basal fibrinolytic activity in 17 children with active juvenile chronic arthritis (JCA) was investigated. It was found that patients with JCA, and particularly those with the systemic form, show decreased plasma fibrinolytic activity and a marked increase in plasminogen activator inhibitor. Additionally, it was found that patients with systemic JCA, but not those with the polyarticular or pauciarticular form, have increased circulating levels of tissue-type plasminogen activator, and endothelial cell protein, suggesting possible endothelial cell participation in systemic JCA.
摘要
对17名患有活动性青少年慢性关节炎（JCA）的儿童的基础纤溶活性进行了研究。发现JCA患者，尤其是全身型患者，血浆纤溶活性降低，纤溶酶原激活物抑制剂显著增加。此外，还发现全身型JCA患者，而非多关节型或少关节型患者，组织型纤溶酶原激活物和内皮细胞蛋白的循环水平升高，提示内皮细胞可能参与全身型JCA。
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