Kolbeck R C, Speir W A, Harrison G N, Vallner J J
Res Commun Chem Pathol Pharmacol. 1979 Mar;23(3):643-6.
The volume of distribution of theophylline at nomal pH, and following induction of respiratory acidosis and alkalosis, was studied in four dogs in a three-way crossover design. Although serum half-lives of theophylline varied widely, and acidemia prolonged the time required for distribution equilibration, the volumes of distribution were almost identical for each of the three experimental conditions assuming one compartment pharmacokinetics apply.
采用三交叉设计，在四只犬中研究了正常pH值以及诱导呼吸性酸中毒和碱中毒后茶碱的分布容积。尽管茶碱的血清半衰期差异很大，且酸血症延长了分布平衡所需的时间，但假设一室药代动力学适用，三种实验条件下的分布容积几乎相同。
