Enhesari Ahmad, Abasnia Roohollah, Baniasad Amir, Narouee Nosrati Shahin, Najafipour Hamid, Najafzadeh Mohammad Javad, Gozashti Mohammad Hossein
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2023 Apr;15(2):93-99. doi: 10.34172/ahj.2023.1388. Epub 2023 Apr 29.
Atherosclerosis has an essential role in causing cardiovascular diseases. Various factors affect the risk of coronary artery atherosclerosis, and the increase in the carotid intima-media thickness (CIMT) is a primary marker for detecting atherosclerotic changes in the artery wall. Since opioid use is one of the leading social and health problems in many countries, this study aimed to detect the factors influencing the increase in CIMT in opium consumers.
This cross-sectional study was conducted on 350 participants of the phase 2 of the KERCADRS cohort study who visited Besat clinic in Kerman and were divided into addicted and non-addicted groups. The participants in both groups underwent carotid artery ultrasound, and the Philips IU22 ultrasound machine was used to measure the CIMT.
The mean age of the participants was 42.28±12.58 in the addicted group and 35.99±15.38 in the non-addicted group (=0.001). CIMT was similar in the two groups (=0.170). Moreover, CIMT had a significant positive correlation with age, waist circumference, systolic blood pressure (SBP), body mass index (BMI), fasting plasma glucose (FPG), and triglyceride in both addicted and non-addicted groups. Age, weight, waist circumference, SBP, and BMI in the multivariate model were significant determinants of CIMT in the addicted group.
The results revealed that age, weight, waist circumference, SBP, and BMI were the factors influencing intima thickness in opium consumers, and no significant relationship was observed between addiction to opium and CIMT.
动脉粥样硬化在引发心血管疾病中起着至关重要的作用。多种因素会影响冠状动脉粥样硬化的风险，而颈动脉内膜中层厚度（CIMT）的增加是检测动脉壁粥样硬化变化的主要指标。由于在许多国家，使用阿片类药物是主要的社会和健康问题之一，本研究旨在检测影响阿片类药物使用者CIMT增加的因素。
本横断面研究针对KERCADRS队列研究第二阶段的350名参与者进行，这些参与者前往克尔曼的贝萨特诊所就诊，并被分为成瘾组和非成瘾组。两组参与者均接受了颈动脉超声检查，并使用飞利浦IU22超声仪测量CIMT。
成瘾组参与者的平均年龄为42.28±12.58岁，非成瘾组为35.99±15.38岁（P=0.001）。两组的CIMT相似（P=0.170）。此外，在成瘾组和非成瘾组中，CIMT与年龄、腰围、收缩压（SBP）、体重指数（BMI）、空腹血糖（FPG）和甘油三酯均呈显著正相关。在多变量模型中，年龄、体重、腰围、SBP和BMI是成瘾组CIMT的显著决定因素。
结果显示，年龄、体重、腰围、SBP和BMI是影响阿片类药物使用者内膜厚度的因素，且未观察到阿片成瘾与CIMT之间存在显著关系。
