Department of Pathology and Medical Sciences, University of Limpopo, Private Bag X1106, Sovenga, South Africa.
BMC Cardiovasc Disord. 2021 Dec 1;21(1):575. doi: 10.1186/s12872-021-02389-5.
Increased waist circumference (WC) is one of the cardiovascular disease (CVD) risk factors used to predict cardiovascular events. Waist circumference cut-off values for predicting metabolic syndrome and other cardiovascular risks have been previously studied. Carotid intima-media thickness (CIMT) is one of the cardiovascular risk factor recently described and reported to be suitable as it is a direct measurement of vascular quality. Hence the aim of the present study was to determine the optimal WC cut-off point for the prediction of subclinical CVD.
The study was a cross-sectional study using quantitative methods, conducted among 1318 adults aged between 40 and 60 years old, residing in a rural Black population in Limpopo province. Carotid Intima-Media Thickness measurements were performed using a LOGIQ ultrasound system (GE Healthcare, CT, USA). Waist Circumference (WC) (cm) was measured to the nearest 0.1 cm. Bivariate correlation, logistic regression and receiver operating characteristic were analysed using the statistical package for social sciences version 26.0 software.
Among the total population, 69% were women and 31% men with a mean age of 53 ± 7 years. Among women, WC at a cut-off value of 95 cm gave the highest sensitivity of 57%, the specificity of 55% and an area under the curve (AUC) of 0.588. In men, an optimum WC cut-off point of 82 cm yielded the highest sensitivity and specificity at 72% and 70% respectively, with an AUC of 0.767 p < 0.001.
The traditional waist circumference cut-off points (94 cm for women and 80 cm for men) that are currently used for the diagnosis of metabolic syndrome might not be suitable in the prediction of an increased CIMT.
腰围（WC）增加是心血管疾病（CVD）的危险因素之一，用于预测心血管事件。已经研究了预测代谢综合征和其他心血管风险的腰围截断值。颈动脉内膜中层厚度（CIMT）是最近描述的心血管危险因素之一，被认为是合适的，因为它是血管质量的直接测量。因此，本研究旨在确定预测亚临床 CVD 的最佳 WC 截断值。
这是一项使用定量方法进行的横断面研究，在林波波省农村黑人人群中，对 1318 名年龄在 40 至 60 岁之间的成年人进行了研究。使用 LOGIQ 超声系统（GE Healthcare，CT，USA）进行颈动脉内膜中层厚度测量。WC（cm）测量到最接近的 0.1cm。使用社会科学统计软件包版本 26.0 软件进行双变量相关性、逻辑回归和接收者操作特征分析。
在总人群中，69%为女性，31%为男性，平均年龄为 53±7 岁。在女性中，WC 截断值为 95cm 时，敏感性最高为 57%，特异性为 55%，曲线下面积（AUC）为 0.588。在男性中，WC 截断值为 82cm 时，敏感性和特异性最高，分别为 72%和 70%，AUC 为 0.767，p<0.001。
目前用于诊断代谢综合征的传统腰围截断值（女性 94cm，男性 80cm）可能不适合预测 CIMT 增加。
