Moitroux Anthony, Kestens Catherine
Hôpital de jour universitaire «La Clé», Liège, Belgique.
Centre Hospitalier Régional de Huy, Belgique.
Rev Med Liege. 2023 Jul;78(7-8):451-455.
Chronic use of gamma-hydroxybutyric acid (GHB) and its precursors can rapidly lead to physical dependence with the emergence of a withdrawal syndrome. This complication is similar to the one linked to alcohol or benzodiazepines. The onset of symptoms and specially neuro-psychiatric symptoms is, however, more rapid in the case of the GHB and precursors. There is currently no consensus on the therapeutic management of GHB withdrawal syndrome. High-dose benzodiazepines are the most commonly used treatment. The use of GHB by titration and tapering could show fewer side effects and withdrawal symptoms. It appears necessary to reflect on and pursue research on the use of GHB and its precursors, which remains poorly understood, on the management of withdrawal syndrome due to the lack of protocol and on its probably underestimated impact on public health.
长期使用γ-羟基丁酸（GHB）及其前体可迅速导致身体依赖，并出现戒断综合征。这种并发症类似于与酒精或苯二氮卓类药物相关的并发症。然而，在GHB及其前体的情况下，症状尤其是神经精神症状的出现更为迅速。目前对于GHB戒断综合征的治疗管理尚无共识。高剂量苯二氮卓类药物是最常用的治疗方法。通过滴定和逐渐减量使用GHB可能副作用和戒断症状更少。鉴于缺乏相关方案以及对其对公众健康的影响可能估计不足，有必要对GHB及其前体的使用进行思考和研究，因为目前对其了解甚少，尤其是在戒断综合征的管理方面。
