靶向 SARM1 可改善自噬应激诱导的轴突神经病。
Targeting SARM1 improves autophagic stress-induced axonal neuropathy.
机构信息
Peripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience and Translational Biomedical Sciences, Dong-A University College of Medicine, Busan, Republic of Korea.
Department of Life Sciences, Division of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
出版信息
Autophagy. 2024 Jan;20(1):29-44. doi: 10.1080/15548627.2023.2244861. Epub 2023 Aug 18.
AAV
adeno-associated virus; ATF3: activating transcription factor 3; ATG7: autophagy related 7; AVIL: advillin; cADPR: cyclic ADP ribose; CALC: calcitonin/calcitonin-related polypeptide; CMT: Charcot-Marie-Tooth disease; cKO: conditional knockout; DEG: differentially expressed gene; DRG: dorsal root ganglion; FE-SEM: field emission scanning electron microscopy; IF: immunofluorescence; NCV: nerve conduction velocity; PVALB: parvalbumin; RAG: regeneration-associated gene; ROS: reactive oxygen species; SARM1: sterile alpha and HEAT/Armadillo motif containing 1; : synapsin I.
AAV
腺相关病毒；ATF3：激活转录因子 3；ATG7：自噬相关 7；AVIL：advillin；cADPR：环 ADP 核糖；CALC：降钙素/降钙素相关多肽；CMT：Charcot-Marie-Tooth 病；cKO：条件性敲除；DEG：差异表达基因；DRG：背根神经节；FE-SEM：场发射扫描电子显微镜；IF：免疫荧光；NCV：神经传导速度；PVALB：parvalbumin；RAG：再生相关基因；ROS：活性氧；SARM1：无菌α和 HEAT/Armadillo 结构域包含 1；synapsin I：突触结合蛋白 I。
Zotero 插件