Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine.
作者信息
Cocker J, Gristwood W, Wilson H K
出版信息
Br J Ind Med. 1986 Sep;43(9):620-5. doi: 10.1136/oem.43.9.620.
Abstract
A new specific and sensitive method has been used to monitor workers from five different factories where 4,4'-diaminodiphenylmethane (methylene dianiline) (DDM) was being used. The isolation and identification of an N-acetyl conjugate of DDM, a major metabolite of DDM found in human urine, is reported for the first time. The use of this biological monitoring method will allow the assessment of the absorption of DDM and help in monitoring improvements in work practices, particularly where exposure may occur through pathways other than inhalation.
摘要
相似文献
1
Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine.
Br J Ind Med. 1986 Sep;43(9):620-5. doi: 10.1136/oem.43.9.620.
2
Determination of the N-acetyl metabolites of 4,4'-methylene dianiline and 4,4'-methylene-bis(2-chloroaniline) in urine.
Biomed Environ Mass Spectrom. 1988 Sep;17(3):161-7. doi: 10.1002/bms.1200170303.
3
A GC/MS method for the determination of 4,4'-diaminodiphenylmethane and substituted analogues in urine.
J Anal Toxicol. 1988 Jan-Feb;12(1):9-14. doi: 10.1093/jat/12.1.9.
4
A biological monitoring assessment of exposure to methylene dianiline in manufacturers and users.制造商和使用者中对亚甲基二苯胺暴露的生物监测评估。
Occup Environ Med. 1994 Aug;51(8):519-22. doi: 10.1136/oem.51.8.519.
5
N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users.尿液样品中的 N-乙酰-4-氨基酚（扑热息痛）、N-乙酰-2-氨基酚和乙酰苯胺，来自一般人群、苯胺接触者和扑热息痛使用者。
Int J Hyg Environ Health. 2014 Apr-May;217(4-5):592-9. doi: 10.1016/j.ijheh.2013.11.005. Epub 2013 Dec 6.
6
Human metabolism and excretion kinetics of aniline after a single oral dose.人单次口服苯胺后的代谢和排泄动力学。
Arch Toxicol. 2016 Jun;90(6):1325-33. doi: 10.1007/s00204-015-1566-x. Epub 2015 Aug 2.
7
Urinary carcinogenic 4-6 ring polycyclic aromatic hydrocarbons in coke oven workers and in subjects belonging to the general population: role of occupational and environmental exposure.焦炉工人和普通人群尿液中的致癌性4-6环多环芳烃：职业暴露和环境暴露的作用
Int J Hyg Environ Health. 2014 Mar;217(2-3):231-8. doi: 10.1016/j.ijheh.2013.06.005. Epub 2013 Jun 20.
8
Proposal for the assessment to quantitative dermal exposure limits in occupational environments: Part 2. Feasibility study for application in an exposure scenario for MDA by two different dermal exposure sampling methods.职业环境中定量皮肤接触限值评估提案：第2部分。两种不同皮肤接触采样方法在MDA暴露场景中应用的可行性研究。
Occup Environ Med. 1998 Dec;55(12):805-11. doi: 10.1136/oem.55.12.805.
9
Identification of metabolites of 4,4'-diaminodiphenylmethane (methylene dianiline) using liquid chromatographic and mass spectrometric techniques.
J Chromatogr. 1992 Nov 27;583(1):63-76. doi: 10.1016/0378-4347(92)80345-q.
10
Biomonitoring of 4,4'-methylene dianiline by measurement in hydrolysed urine and plasma after epicutaneous exposure in humans.人体经皮暴露后通过测定水解尿液和血浆来对4,4'-亚甲基二苯胺进行生物监测。
Int Arch Occup Environ Health. 1995;67(2):95-100. doi: 10.1007/BF00572232.
引用本文的文献
1
Characterization of biliary conjugates of 4,4'-methylenedianiline in male versus female rats.雄性与雌性大鼠中4,4'-亚甲基二苯胺的胆汁共轭物特性研究
Toxicol Appl Pharmacol. 2008 Oct 15;232(2):190-202. doi: 10.1016/j.taap.2008.06.008. Epub 2008 Jul 1.
2
Determination of urinary 4,4'-methylenedianiline and its acetylated metabolites by solid-phase extraction and HPLC analysis with UV and electrochemical detection.
Int Arch Occup Environ Health. 1995;68(1):44-51. doi: 10.1007/BF01831632.
3
A biological monitoring assessment of exposure to methylene dianiline in manufacturers and users.制造商和使用者中对亚甲基二苯胺暴露的生物监测评估。
Occup Environ Med. 1994 Aug;51(8):519-22. doi: 10.1136/oem.51.8.519.
4
4,4'-Methylenedianiline in hydrolysed serum and urine from a worker exposed to thermal degradation products of methylene diphenyl diisocyanate elastomers.一名接触亚甲基二苯基二异氰酸酯弹性体热降解产物的工人水解血清和尿液中的4,4'-亚甲基二苯胺
Int Arch Occup Environ Health. 1995;67(2):73-7. doi: 10.1007/BF00572229.
5
Assessment of occupational exposure to 4,4'-methylenedianiline by the analysis of urine and blood samples.
Int Arch Occup Environ Health. 1995;67(2):67-72. doi: 10.1007/BF00572228.
6
Evidence that a beta-N-glucuronide of 4,4'-methylenebis (2-chloroaniline) (MbOCA) is a major urinary metabolite in man: implications for biological monitoring.4,4'-亚甲基双（2-氯苯胺）（MbOCA）的β-N-葡萄糖醛酸苷是人体主要尿液代谢物的证据：对生物监测的意义。
Br J Ind Med. 1990 Mar;47(3):154-61. doi: 10.1136/oem.47.3.154.
本文引用的文献
1
Determination of 4,4'-diaminodiphenylmethane in blood by gas-liquid chromatography with electron-capture detection.
J Chromatogr. 1983 Jun 24;262:367-72. doi: 10.1016/s0021-9673(01)88122-x.
2
The determination of 4,4'-methylenebis (2-chloroaniline) in urine by electron capture gas chromatography.
J Anal Toxicol. 1984 May-Jun;8(3):101-5. doi: 10.1093/jat/8.3.101.
3
Biological monitoring of workers exposed to 4,4'-methylenebis (2-chloroaniline) (MBOCA).对接触4,4'-亚甲基双（2-氯苯胺）（MBOCA）的工人进行生物监测。
Br J Ind Med. 1984 Nov;41(4):547-51. doi: 10.1136/oem.41.4.547.
4
5
Metabolism of the human carcinogen, benzidine, in the isolated perfused rat liver.
Drug Metab Dispos. 1983 Mar-Apr;11(2):109-14.
6
Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer.N-乙酰转移酶表型在膀胱癌发生中的作用：一种膀胱癌的药物遗传学流行病学研究方法
Lancet. 1982 Oct 16;2(8303):842-5. doi: 10.1016/s0140-6736(82)90810-8.
7
The Epping jaundice.埃平黄疸
Br Med J. 1966 Feb 26;1(5486):514-6. doi: 10.1136/bmj.1.5486.514.
8
9
Letter: Toxic hepatitis and methylenedianiline.
N Engl J Med. 1974 Dec 5;291(23):1256.
10
An industrial outbreak of toxic hepatitis due to methylenedianiline.
N Engl J Med. 1974 Aug 8;291(6):278-82. doi: 10.1056/NEJM197408082910604.
Zotero 插件