对接触4,4'-亚甲基双（2-氯苯胺）（MBOCA）的工人进行生物监测。
Biological monitoring of workers exposed to 4,4'-methylenebis (2-chloroaniline) (MBOCA).
作者信息
Thomas J D, Wilson H K
出版信息
Br J Ind Med. 1984 Nov;41(4):547-51. doi: 10.1136/oem.41.4.547.
Abstract
A biological monitoring programme has been developed for assessing occupational exposure to 4,4'-methylenebis (2-chloroaniline) (MBOCA) in a factory which manufactures polyurethane elastomers. In a systematic programme of biological monitoring over a five year period urinary MBOCA concentrations have been used to provide evidence of absorption of MBOCA. Improvements in the handling and use of MBOCA have coincided with a steady reduction in the urinary MBOCA concentrations.
摘要
已制定了一项生物监测计划，用于评估一家生产聚氨酯弹性体的工厂中工人职业接触4,4'-亚甲基双（2-氯苯胺）（MBOCA）的情况。在一项为期五年的系统生物监测计划中，尿中MBOCA浓度被用于提供MBOCA吸收情况的证据。MBOCA处理和使用方法的改进与尿中MBOCA浓度的稳步下降同时出现。
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本文引用的文献
1
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Toxicol Appl Pharmacol. 1981 Apr;58(2):231-5. doi: 10.1016/0041-008x(81)90427-0.
2
The metabolism and distribution of 4,4'-methylene-bis(2-chloroaniline) (MBOCA) in rats.
J Appl Toxicol. 1981 Dec;1(6):317-22. doi: 10.1002/jat.2550010610.
3
Methylene-bis-ortho-chloroaniline (MOCA): evaluation of hazards and exposure control.
Am Ind Hyg Assoc J. 1971 Dec;32(12):802-19. doi: 10.1080/0002889718506543.
4
Benzidine exposure as a cause of bladder tumors.
Arch Environ Health. 1973 Jul;27(1):1-7. doi: 10.1080/00039896.1973.10666297.
5
Precautions in the use of methylene-bis-omicron-chloroaniline (MBOCA).
Ann Occup Hyg. 1974 Dec;17(2):137-42. doi: 10.1093/annhyg/17.2.137.
6
The carcinogenic effect of 4,4'-methylene-bis-(2-chloroaniline) in mice and rats.
Toxicol Appl Pharmacol. 1975 Jan;31(1):47-54. doi: 10.1016/0041-008x(75)90050-2.
7
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.在沙门氏菌/微粒体试验中作为诱变剂的致癌物检测：300种化学物质的测定
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9. doi: 10.1073/pnas.72.12.5135.
8
Liver and lung tumors in dogs from 4,4'-methylene-bis(2-methylaniline).
J Environ Pathol Toxicol. 1978 Jan-Feb;1(3):339-56.
9
Urinary bladder tumors in dogs from 4,4'-methylene-bis (2-chloroaniline) (MOCA).
J Environ Pathol Toxicol. 1978 Sep-Oct;1(1):31-50.
10
Acute exposure to methylene-bis-ortho chloroaniline (MOCA).
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