Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Pediatr Blood Cancer. 2023 Nov;70(11):e30624. doi: 10.1002/pbc.30624. Epub 2023 Aug 10.
Nephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect.
A systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT.
A pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD -0.11 [95% CI -1.07-0.84] p = .733).
The current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.
儿童肾肿瘤治疗后可能会出现肾毒性副作用。放射治疗（RT）的应用可能会有额外的影响。
对 EMBASE 中与儿童肾肿瘤的不同治疗方法和肾毒性相关的文献进行了系统的电子文献检索。本研究纳入了儿童时期接受肾肿瘤治疗后出现肾毒性的报道，75%的参与者在诊断时年龄小于 25 岁，且接受过任何类型的肾手术、化疗和/或 RT 治疗。
对患者的估计肾小球滤过率进行合并分析显示，接受 RT 治疗的组与未接受 RT 治疗的组之间无显著差异（SMD-0.11 [95% CI-1.07-0.84]，p=0.733）。
目前的文献表明，RT 的应用作为一个独立因素对肾功能下降没有显著影响。
