Int J Gynecol Pathol. 2024 Mar 1;43(2):140-144. doi: 10.1097/PGP.0000000000000971. Epub 2023 Jul 18.
Sertoli-Leydig cell tumors (SLCT) are rare tumors of the ovary with a peak incidence in the second to third decade of life. Serous borderline tumors (SBT) are epithelial ovarian neoplasms which occur at a median age of 50 years. A co-occurrence of SLCT and SBT has not yet been reported. Here, we describe a case of a 16-year-old girl who presented with irregular menses, virilization, and an abdominopelvic mass. The mass was surgically removed and an intraoperative consultation revealed an 18.5 cm solid and cystic ovarian mass with the presence of co-existing SLCT and SBT. The diagnosis was confirmed on permanent sections after extensive sampling and immunohistochemical stains. The SLCT showed positive staining for calretinin, inhibin, CD99, and androgen receptor. MART-1 immunostain highlighted the Leydig cells. The SBT showed classic features including hierarchically branching papillae lined by stratified serous epithelium. This pediatric case is the first reported case of a Sertoli-Leydig cell tumor arising in association with a serous borderline tumor.
支持细胞瘤-间质细胞瘤（SLCT）是一种罕见的卵巢肿瘤，发病高峰在第二至第三个十年。浆液性交界性肿瘤（SBT）是一种上皮性卵巢肿瘤，中位发病年龄为 50 岁。SLCT 和 SBT 同时发生尚未见报道。本文描述了一例 16 岁女孩，因月经不规则、男性化和腹部盆腔肿块就诊。肿块经手术切除，术中会诊发现一个 18.5 厘米的实性和囊性卵巢肿块，并存 SLCT 和 SBT。广泛取样和免疫组化染色后，在石蜡切片上确诊。SLCT 对 calretinin、inhibin、CD99 和雄激素受体呈阳性染色。MART-1 免疫染色突出了间质细胞。SBT 表现出经典特征，包括由复层浆液上皮排列的分级分支乳头。这个儿科病例是首例报道的支持细胞瘤-间质细胞瘤与浆液性交界性肿瘤相关的病例。
