French T J, Goode A W, Schofield P S, Sugden M C
Biochim Biophys Acta. 1986 Oct 1;883(3):396-9. doi: 10.1016/0304-4165(86)90275-8.
Rats subjected to laparotomy and handling of the liver were starved for 48 h, starting either immediately after surgery or 48 h later. Surgery enhanced the rise in plasma non-esterified fatty acid concentrations after starvation without affecting the responses of blood or liver ketone bodies. Thus in surgically stressed rats, blood and liver ketone body concentrations were inappropriately low for the blood fatty acid concentrations. In the control rats, starvation increased hepatic carnitine concentrations, mainly through increases in short-chain acylcarnitine. Surgical stress decreased or abolished these increases. This may possibly contribute to the blunted ketonaemic response observed after surgery.
接受剖腹手术并处理肝脏的大鼠禁食48小时，禁食从手术后立即开始或在48小时后开始。手术增强了饥饿后血浆非酯化脂肪酸浓度的升高，而不影响血液或肝脏酮体的反应。因此，在手术应激的大鼠中，血液和肝脏酮体浓度相对于血液脂肪酸浓度而言过低。在对照大鼠中，饥饿主要通过短链酰基肉碱的增加来提高肝脏肉碱浓度。手术应激降低或消除了这些增加。这可能是导致手术后酮血症反应减弱的原因。
