Schofield P S, McLees D J, Myles D D, Sugden M C
Biochem J. 1985 Oct 1;231(1):225-8. doi: 10.1042/bj2310225.
Fed or 24 h-starved rats were subjected to two-thirds partial hepatectomy or sham-operation and subsequently starved for 4, 14 or 24 h. Despite high plasma fatty acid concentrations, the partially hepatectomized rats failed to respond to post-operative starvation with increased blood and liver ketone-body concentrations or to maintain the high ketone-body concentrations associated with pre-operative starvation. Hypoglycaemia and hyperlactaemia were observed within 30 min of functional hepatectomy, but not partial hepatectomy, of 24 h-starved rats, and, even after a further 24 h starvation of partially hepatectomized rats, blood glucose concentrations were only slightly decreased. The results are discussed with reference to fat oxidation and gluconeogenesis in the liver remaining after partial hepatectomy.
对喂食的或饥饿24小时的大鼠进行三分之二部分肝切除术或假手术，随后再饥饿4、14或24小时。尽管血浆脂肪酸浓度很高，但部分肝切除的大鼠术后饥饿时血液和肝脏酮体浓度并未升高，也未能维持术前饥饿时的高酮体浓度。在对饥饿24小时的大鼠进行功能性肝切除而非部分肝切除后30分钟内观察到低血糖和高乳酸血症，而且即使部分肝切除的大鼠再饥饿24小时后，血糖浓度也只是略有下降。结合部分肝切除后残留肝脏中的脂肪氧化和糖异生对结果进行了讨论。
