再喂养后肝脏中脂肪合成与氧化的关系及其受甲状腺激素的调节。
The relationship between fat synthesis and oxidation in the liver after re-feeding and its regulation by thyroid hormone.
作者信息
Holness M J, French T J, Schofield P S, Sugden M C
机构信息
Department of Chemical Pathology, London Hospital Medical College, U.K.
出版信息
Biochem J. 1987 Nov 1;247(3):621-6. doi: 10.1042/bj2470621.
Abstract
The administration of glucose to 48 h-starved euthyroid or hyperthyroid rats led to decreased blood concentrations of fatty acids and ketone bodies in both groups, but fatty acid concentrations were higher and ketone-body concentrations lower in the latter group. Decreased ketonaemia was not due to increased ketone-body clearance. Flux through carnitine palmitoyltransferase 1 was increased, consistent with the effects of hyperthyroidism on enzyme activity demonstrated in vitro. Correlations between the concentrations of ketone bodies and long-chain acylcarnitine measured in freeze-clamped liver samples indicated that a lower proportion of the product of beta-oxidation was used for ketone-body synthesis. Citrate concentrations were unaffected by hyperthyroidism, but lipogenesis was increased. The results are discussed in relation to the factors controlling hepatic carbon flux and energy requirements after re-feeding.
摘要
对饥饿48小时的正常甲状腺或甲状腺功能亢进大鼠给予葡萄糖后，两组大鼠的血液中脂肪酸和酮体浓度均降低，但后一组的脂肪酸浓度较高，酮体浓度较低。酮血症降低并非由于酮体清除增加所致。肉碱棕榈酰转移酶1的通量增加，这与甲状腺功能亢进对体外所证实的酶活性的影响一致。在冷冻钳夹的肝脏样本中测得的酮体浓度与长链酰基肉碱浓度之间的相关性表明，β氧化产物用于酮体合成的比例较低。柠檬酸浓度不受甲状腺功能亢进的影响，但脂肪生成增加。结合再喂养后控制肝脏碳通量和能量需求的因素对结果进行了讨论。
相似文献
1
The relationship between fat synthesis and oxidation in the liver after re-feeding and its regulation by thyroid hormone.再喂养后肝脏中脂肪合成与氧化的关系及其受甲状腺激素的调节。
Biochem J. 1987 Nov 1;247(3):621-6. doi: 10.1042/bj2470621.
2
Altered interactions between lipogenesis and fatty acid oxidation in regenerating rat liver.再生大鼠肝脏中脂肪生成与脂肪酸氧化之间的相互作用改变
Biochem J. 1987 Jan 15;241(2):469-74. doi: 10.1042/bj2410469.
3
Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.脂肪酸和甲状腺激素对肝脏丙酮酸脱氢酶激酶同工型2和4蛋白表达调控的潜在机制研究
Biochem J. 2003 Feb 1;369(Pt 3):687-95. doi: 10.1042/BJ20021509.
4
Liver carnitine metabolism after partial hepatectomy in the rat. Effects of nutritional status and inhibition of carnitine palmitoyltransferase.大鼠部分肝切除术后肝脏肉碱代谢。营养状况及肉碱棕榈酰转移酶抑制的影响。
FEBS Lett. 1985 May 20;184(2):214-20. doi: 10.1016/0014-5793(85)80609-8.
5
Effects of surgical stress on the response of hepatic carnitine metabolism to 48 h starvation in the rat.手术应激对大鼠肝脏肉碱代谢在48小时饥饿状态下反应的影响。
Biochim Biophys Acta. 1986 Oct 1;883(3):396-9. doi: 10.1016/0304-4165(86)90275-8.
6
The outer carnitine palmitoyltransferase and regulation of fatty acid metabolism in rat liver in different thyroid states.大鼠肝脏中不同甲状腺状态下的外源性肉碱棕榈酰转移酶与脂肪酸代谢调控
Biochim Biophys Acta. 1983 Feb 7;750(2):244-52. doi: 10.1016/0005-2760(83)90025-5.
7
Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats.慢性给予硫代乙酰胺对大鼠肝脏脂肪酸代谢的影响
Hepatology. 1992 Jun;15(6):1099-106. doi: 10.1002/hep.1840150621.
8
beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats.在肉碱缺乏、经新戊酸处理的大鼠中，β-羟基丁酸氧化减少，酮体与游离脂肪酸的肝脏平衡未改变。
J Nutr. 1996 Nov;126(11):2867-72. doi: 10.1093/jn/126.11.2867.
9
Rapid switch of hepatic fatty acid metabolism from oxidation to esterification during diurnal feeding of meal-fed rats correlates with changes in the properties of acetyl-CoA carboxylase, but not of carnitine palmitoyltransferase I.在定时喂食的大鼠每日进食期间，肝脏脂肪酸代谢从氧化迅速转变为酯化，这与乙酰辅酶A羧化酶性质的变化相关，但与肉碱棕榈酰转移酶I的性质变化无关。
Biochem J. 1993 Apr 1;291 ( Pt 1)(Pt 1):241-6. doi: 10.1042/bj2910241.
10
Relationships between fatty acid synthesis and lipid secretion in the isolated perfused rat liver: effects of hyperthyroidism, glucose and oleate.离体灌注大鼠肝脏中脂肪酸合成与脂质分泌的关系：甲状腺功能亢进、葡萄糖和油酸的影响
Biochim Biophys Acta. 1991 Nov 5;1086(2):197-208. doi: 10.1016/0005-2760(91)90008-6.
引用本文的文献
1
Reprogramming of aerobic glycolysis in non-transformed mouse liver with pyruvate dehydrogenase complex deficiency.丙酮酸脱氢酶复合体缺陷的非转化型小鼠肝中糖酵解的重新编程。
Physiol Rep. 2021 Jan;9(1):e14684. doi: 10.14814/phy2.14684.
2
Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice.小鼠肝脏在禁食和再进食时为维持代谢稳态所做出的适应性变化。
Nutr Metab (Lond). 2016 Sep 26;13:62. doi: 10.1186/s12986-016-0122-x. eCollection 2016.
3
Cross-talk between the thyroid and liver: a new target for nonalcoholic fatty liver disease treatment.甲状腺与肝脏的相互作用：非酒精性脂肪性肝病治疗的新靶点。
World J Gastroenterol. 2013 Dec 7;19(45):8238-46. doi: 10.3748/wjg.v19.i45.8238.
4
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.甲状腺激素通过 PPARα 依赖性方式调节肝组织中纤维母细胞生长因子 21 的表达。
J Biol Chem. 2010 May 7;285(19):14078-82. doi: 10.1074/jbc.C110.107375. Epub 2010 Mar 17.
5
Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart.甲状腺素对大鼠心脏中单溶血心磷脂酰基转移酶活性的调节
Biochem J. 2000 Mar 1;346 Pt 2(Pt 2):403-6.
6
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis.线粒体3-羟基-3-甲基戊二酰辅酶A合酶：酮体生成中的一种调控酶。
Biochem J. 1999 Mar 15;338 ( Pt 3)(Pt 3):569-82.
7
Monitoring of changes in hepatic fatty acid and glycerolipid metabolism during the starved-to-fed transition in vivo. Studies on awake, unrestrained rats.体内饥饿至进食转变过程中肝脏脂肪酸和甘油脂质代谢变化的监测。对清醒、不受束缚大鼠的研究。
Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):49-55. doi: 10.1042/bj2890049.
8
Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats.钒酸盐处理可恢复糖尿病大鼠肝脏中葡萄糖和酮体代谢关键酶基因的表达。
J Clin Invest. 1993 Jul;92(1):4-11. doi: 10.1172/JCI116580.
9
Hepatic carbon flux after re-feeding in the glycogen-storage-disease (gsd/gsd) rat.糖原贮积病（gsd/gsd）大鼠再喂养后的肝脏碳通量。
Biochem J. 1987 Dec 15;248(3):969-72. doi: 10.1042/bj2480969.
10
Regulation of hepatic fructose 2,6-bisphosphate concentrations and lipogenesis after re-feeding in euthyroid and hyperthyroid rats. A regulatory role for glycogenesis.正常甲状腺和甲状腺功能亢进大鼠再喂食后肝脏中果糖-2,6-二磷酸浓度及脂肪生成的调节。糖原生成的调节作用。
Biochem J. 1988 Jun 1;252(2):357-62. doi: 10.1042/bj2520357.
本文引用的文献
1
Effect of hyperthyroidism and hypothyroidism on lipid and carbohydrate metabolism of the perfused rat liver.甲状腺功能亢进和减退对灌注大鼠肝脏脂质及碳水化合物代谢的影响。
Biochem J. 1981 Apr 15;196(1):247-55. doi: 10.1042/bj1960247.
2
Effects of fasting, adrenalectomy and streptozotocin-diabetes on sensitivity of hepatic carnitine acyltransferase to malonyl CoA.禁食、肾上腺切除及链脲佐菌素诱导的糖尿病对肝脏肉碱酰基转移酶对丙二酰辅酶A敏感性的影响。
FEBS Lett. 1981 Jul 6;129(2):225-8. doi: 10.1016/0014-5793(81)80170-6.
3
Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.脂肪酸氧化抑制剂2-十四烷基缩水甘油酸对饥饿和四氧嘧啶糖尿病大鼠丙酮酸脱氢酶复合体活性的影响。
Biochem J. 1982 Oct 15;208(1):53-60. doi: 10.1042/bj2080053.
4
Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.在分离的大鼠肝脏线粒体中，肉碱酰基转移酶I对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度存在定量关系。
Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.
5
The metabolism of fatty acids in hepatocytes isolated from triiodothyronine-treated rats.
Biochim Biophys Acta. 1982 Apr 15;711(1):90-100. doi: 10.1016/0005-2760(82)90013-3.
6
The outer carnitine palmitoyltransferase and regulation of fatty acid metabolism in rat liver in different thyroid states.大鼠肝脏中不同甲状腺状态下的外源性肉碱棕榈酰转移酶与脂肪酸代谢调控
Biochim Biophys Acta. 1983 Feb 7;750(2):244-52. doi: 10.1016/0005-2760(83)90025-5.
7
Regulation of hepatic lipogenesis in starved and diabetic animals by thyroid hormone.甲状腺激素对饥饿和糖尿病动物肝脏脂肪生成的调节作用。
Biosci Rep. 1981 Oct;1(10):757-64. doi: 10.1007/BF01114797.
8
Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway.再喂养大鼠中高效的肝糖原合成需要通过糖异生途径持续的碳流。
J Biol Chem. 1984 Jun 10;259(11):6958-63.
9
10
Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats.禁食大鼠重新进食期间肝脏果糖-2,6-二磷酸水平变化的时间进程及意义
J Clin Invest. 1984 Sep;74(3):1108-11. doi: 10.1172/JCI111479.
Zotero 插件