miR-151a-5p 在肿瘤发生中的作用：系统评价。

The role of mir-151a-5p in tumorigenesis; A systematic review.

机构信息

Department of Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Genetics, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Genetics, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Pathol Res Pract. 2023 Sep;249:154576. doi: 10.1016/j.prp.2023.154576. Epub 2023 Jun 1.

DOI:10.1016/j.prp.2023.154576

PMID:37562284

Abstract

BACKGROUND

Highly supported microRNAs (miRNAs) are key players in cancer development. Each of these miRNAs may act as an oncomir, a tumor-suppressor, or both in various cancers. Mir-151a-5p is believed to be one of these miRNAs with diverse roles. We have conducted this systematic review to clarify the role of mir-151a-5p in formation of various cancers.

METHODS AND MATERIALS

We searched for existing articles in PubMed, Web of Science, Cochrane, Scopus, and RNAcentral databases up to November 2022. A total of 23 articles were qualified and included in the present systematic review. This review is registered on JBI at https://jbi.global/systematic-review-register. Expression levels, diagnostic and prognostic values, biological processes, and targeted downstream genes are included.

RESULTS

Assembled data indicate the expression levels of mir-151a-5p vary from down- to up-regulated based on the type of the cancer. Its functional role depends on the genetic profile of cancerous tissue. Results mostly point to the oncogenic role of this miRNA in Pituitary adenomas, Acute Myeloid Leukemia (AML), Endometrial, Lung, Barrett's carcinogenesis, Colorectal, Myelodysplastic syndromes, Hepatocellular carcinoma and Breast cancers, as its inhibited targets seem to be controlling several signaling pathways, cell adhesion, and cell cycle. At the same time, tumor-suppressing role has also been observed only in Malignant Pleural Mesothelioma, Central Nerve System (CNS) lymphoma, Chronic Myeloid and Acute Lymphocytic Leukemia. Two types of cancers, prostate and colon, show contradictory results as there are studies supporting both up- and down-regulation in these cancers. Pituitary adenomas, Barrett's carcinogenesis and CNS lymphomas are top cancers diagnosed with mir-151-5p. However, prognostic feature is only applicable to Lung adenocarcinoma.

DISCUSSION

Based on the present findings and further studies in the future, mir-151a-5p may be used as diagnostic and prognostic biomarkers or even a therapeutic target in cancer studies.

DATA AVAILABILITY STATEMENT

The articles used in this study can be found with the defined search phrase in mentioned databases. A list of selected articles will be available on reasonable requests.

摘要

背景

高度支持的 microRNAs（miRNAs）是癌症发展的关键参与者。这些 miRNA 中的每一种都可能在各种癌症中充当癌基因、肿瘤抑制因子，或两者兼有。miR-151a-5p 被认为是具有多种作用的 miRNA 之一。我们进行了这项系统评价，以阐明 mir-151a-5p 在各种癌症形成中的作用。

方法和材料

我们在 PubMed、Web of Science、Cochrane、Scopus 和 RNAcentral 数据库中搜索了截至 2022 年 11 月的现有文章。共有 23 篇文章符合条件并纳入本系统评价。本综述在 JBI 上注册，网址为 https://jbi.global/systematic-review-register。包括表达水平、诊断和预后价值、生物学过程和靶向下游基因。

结果

综合数据表明，根据癌症类型的不同，mir-151a-5p 的表达水平从下调到上调不等。其功能作用取决于癌组织的遗传特征。结果大多指向该 miRNA 在垂体腺瘤、急性髓系白血病 (AML)、子宫内膜、肺癌、巴雷特癌变、结直肠癌、骨髓增生异常综合征、肝癌和乳腺癌中的致癌作用，因为其被抑制的靶标似乎控制着几种信号通路、细胞黏附和细胞周期。同时，也仅在恶性胸膜间皮瘤、中枢神经系统 (CNS) 淋巴瘤、慢性髓性和急性淋巴细胞白血病中观察到肿瘤抑制作用。前列腺癌和结肠癌这两种癌症的结果相互矛盾，因为有研究支持这两种癌症中存在上调和下调。垂体腺瘤、巴雷特癌变和 CNS 淋巴瘤是诊断 mir-151-5p 的顶级癌症。然而，预后特征仅适用于肺腺癌。