Sharma Yamini, Shankar Vijayalakshmi
School of Biosciences and Technology, Vellore Institute of Technology, Vellore - 14, India.
CO(2) Research and Green Technologies Centre, Vellore Institute of Technology, Vellore - 14, India.
Int J Biol Macromol. 2023 Oct 1;250:126194. doi: 10.1016/j.ijbiomac.2023.126194. Epub 2023 Aug 8.
Three-Dimensional bioprinting has recently gained more attraction among researchers for its wide variety of applicability. This technology involving in developing structures that mimic the natural anatomy, and also aims in developing novel biomaterials, bioinks which have a better printable ability. Different hydrogels (cross-linked polysaccharides) can be used and optimized for good adhesion and cell proliferation. Manufacturing hydrogels with adjustable characteristics allows for fine-tuning of the cellular microenvironment. Different printing technologies can be used to create hydrogels on a micro-scale which will allow regular, patterned integration of cells into hydrogels. Controlling tissue constructions' structural architecture is the important key to ensuring its function as it is designed. The designed tiny hydrogels will be useful in investigating the cellular behaviour within the environments. Three-Dimensional designs can be constructed by modifying their shape and behaviour analogous concerning pressure, heat, electricity, ultraviolet radiation or other environmental elements. Yet, its application in in vitro infection models needs more research and practical study. Microbial bioprinting has become an advancing field with promising potential to develop various biomedical as well as environmental applications. This review elucidates the properties and usage of different hydrogels for Three-Dimensional bioprinting.
三维生物打印技术因其广泛的适用性，近年来在研究人员中越来越受到关注。这项技术涉及开发模仿自然解剖结构的结构，同时也致力于开发具有更好可打印能力的新型生物材料和生物墨水。不同的水凝胶（交联多糖）可用于并进行优化，以实现良好的粘附性和细胞增殖。制造具有可调节特性的水凝胶能够对细胞微环境进行微调。不同的打印技术可用于在微观尺度上制造水凝胶，这将使细胞能够以规则的、有图案的方式整合到水凝胶中。控制组织结构的结构架构是确保其按设计发挥功能的关键。设计的微小水凝胶将有助于研究细胞在环境中的行为。三维设计可以通过改变其形状以及在压力、热、电、紫外线辐射或其他环境因素方面的类似行为来构建。然而，其在体外感染模型中的应用需要更多的研究和实践探索。微生物生物打印已成为一个不断发展的领域，在开发各种生物医学和环境应用方面具有广阔的潜力。这篇综述阐明了用于三维生物打印的不同水凝胶的特性和用途。
