Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, US.
Laboratory of Retrovirology, The Rockefeller University, New York, NY, US.
Nat Commun. 2023 Aug 10;14(1):4598. doi: 10.1038/s41467-023-39989-y.
The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV-2 variant pseudotypes in a subset of 259 patients and determined correlation between IgG levels and variant neutralizing activity. We further study the ability of maternal antibody and neutralizing measurements to predict neutralizing antibody activity in the umbilical cord blood of neonates. In this work, we show SARS-CoV-2 vaccination and boosting, especially in the setting of previous infection, leads to significant increases in antibody levels and neutralizing activity even against the recent omicron BA.1 and BA.5 variants in both pregnant patients and their neonates.
先前和怀孕期间异源感染、接种疫苗和加强免疫史的影响尚未得到广泛研究，但对于保护新生儿可能很重要。我们测量了 4600 名患者及其具有不同疫苗接种状态的新生儿的刺突结合抗体水平，包括有和没有 SARS-CoV-2 感染史的患者。我们在 259 名患者的亚组中研究了针对不同 SARS-CoV-2 变体假型的中和抗体活性，并确定了 IgG 水平与变体中和活性之间的相关性。我们进一步研究了母体抗体和中和测量值预测新生儿脐带血中中和抗体活性的能力。在这项工作中，我们表明 SARS-CoV-2 接种和加强免疫，特别是在先前感染的情况下，即使是针对最近的 omicron BA.1 和 BA.5 变体，也会导致孕妇及其新生儿的抗体水平和中和活性显著增加。
