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Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.孕期混合免疫对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的中和及结合抗体反应
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Impact of Antenatal SARS-CoV-2 Exposure on SARS-CoV-2 Neutralization Potency.产前接触严重急性呼吸综合征冠状病毒2对严重急性呼吸综合征冠状病毒2中和效力的影响。
Vaccines (Basel). 2024 Feb 5;12(2):164. doi: 10.3390/vaccines12020164.
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Neonatal SARS-CoV-2 immunoglobulin G antibodies at delivery and their impact on COVID-19.分娩时新生儿 SARS-CoV-2 免疫球蛋白 G 抗体及其对 COVID-19 的影响。
Eur J Clin Microbiol Infect Dis. 2024 Apr;43(4):693-702. doi: 10.1007/s10096-024-04773-3. Epub 2024 Feb 7.
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COVID-19 vaccine induced poor neutralization titers for SARS-CoV-2 omicron variants in maternal and cord blood.COVID-19 疫苗诱导母血和脐血中针对 SARS-CoV-2 奥密克戎变异株的中和效价较低。
Front Immunol. 2023 Jul 3;14:1211558. doi: 10.3389/fimmu.2023.1211558. eCollection 2023.

母体和新生儿对严重急性呼吸综合征冠状病毒 2 奥密克戎变异株的中和作用，产前信使 RNA 疫苗接种后。

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination.

机构信息

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Clinical Virology Unit, Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

出版信息

Clin Infect Dis. 2022 Nov 30;75(11):2023-2026. doi: 10.1093/cid/ciac395.

DOI:10.1093/cid/ciac395
PMID:35607735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9213860/
Abstract

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

摘要

我们评估了产前接种 BNT162b2 后母血和脐血血清对 SARS-CoV-2 奥密克戎变异株的中和效率。两剂疫苗接种后，产妇分娩时缺乏针对奥密克戎的中和抗体。对于母亲和新生儿建立针对奥密克戎的中和抗体能力，第三剂加强针是必不可少的。