Department of Ophthalmology, Dongguk University Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Sci Rep. 2023 Aug 10;13(1):12982. doi: 10.1038/s41598-023-40183-9.
The purpose of this study was to investigate the effects of intraoperative fibrin glue use on surgery for blepharoptosis. This retrospective study included patients with acquired blepharoptosis who underwent surgical correction and were followed for at least one month. Patients were classified into two groups depending on whether treated with antithrombotic agents or otherwise. All patients taking antithrombotic agents discontinued with the treatment one week prior to surgery in accordance with our clinical guidelines. Preoperative and postoperative marginal reflex distance 1(MRD1) and ecchymosis grade were evaluated and compared. The subjects were 56 patients (111 eyes) who discontinued antithrombotic agents before surgery and 59 patients (117 eyes) who had never taken antithrombotic agents. Fibrin glue was used in 13 patients (26 eyes, 23.4%) in the antithrombotic group, and 11 patients (21 eyes, 17.9%) in the non-antithrombotic group. The rate of severe ecchymosis was significantly lower in patients who used fibrin glue in the antithrombotic group at 1 week (11.5 vs 40.0%, p = 0.008). However, in non-antithrombotic group, there was no difference in the rate of severe ecchymosis according to the use of fibrin glue at 1 week (14.3 vs 30.2%, p = 0.181). In patients with a history of taking antithrombotic agents, the intraoperative use of fibrin glue is thought to be helpful as it could significantly reduce significant ecchymosis.
本研究旨在探讨术中使用纤维蛋白胶对眼睑下垂手术的影响。本回顾性研究纳入了接受手术矫正的获得性眼睑下垂患者，并进行了至少一个月的随访。根据是否使用抗血栓药物将患者分为两组。所有服用抗血栓药物的患者均按照我们的临床指南在手术前一周停止治疗。评估并比较了术前和术后的边缘反射距离 1（MRD1）和瘀斑分级。本研究共纳入了 56 例（111 只眼）术前停用抗血栓药物的患者和 59 例（117 只眼）从未服用过抗血栓药物的患者。在抗血栓组中，有 13 例（26 只眼，23.4%）患者使用了纤维蛋白胶，而非抗血栓组中有 11 例（21 只眼，17.9%）患者使用了纤维蛋白胶。在抗血栓组中，使用纤维蛋白胶的患者在术后 1 周时严重瘀斑的发生率明显较低（11.5%比 40.0%，p=0.008）。然而，在非抗血栓组中，使用纤维蛋白胶与术后 1 周时严重瘀斑的发生率无差异（14.3%比 30.2%，p=0.181）。对于有服用抗血栓药物史的患者，术中使用纤维蛋白胶可能有助于显著减少明显的瘀斑。
