Smirnov V A, Vladeeva N V, Lobzin V S, Paniukov A N
Biull Eksp Biol Med. 1986 Sep;102(9):275-6.
Using the immunohistochemical technique, it was revealed that serum immunoglobulins of patients with myasthenia gravis (Ig) were irreversibly attached to the myoneuronal connections of the rat intercostal muscles like the marker of the nicotin cholinireceptors--the cobra venom neurotoxin (CT). In addition, Ig differs from CT in the binding to nervous cells of the claustrum and diencephalon reticular formation and with certain cells of the nucleus caudatus and hemispheric cerebral cortex. It is suggested that the autoimmune processes in patients with myasthenia gravis do not only involve myoneuronal connection but also participate in central mechanisms of the disease genesis.
采用免疫组织化学技术发现，重症肌无力患者的血清免疫球蛋白（Ig）不可逆地附着于大鼠肋间肌的肌神经连接部位，就如同烟碱型胆碱能受体的标志物——眼镜蛇毒神经毒素（CT）一样。此外，Ig在与屏状核、间脑网状结构的神经细胞以及尾状核和大脑半球皮质某些细胞的结合方面与CT不同。提示重症肌无力患者的自身免疫过程不仅涉及肌神经连接，还参与了疾病发生的中枢机制。
