Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.
Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.
Sci Rep. 2023 Aug 10;13(1):12960. doi: 10.1038/s41598-023-40299-y.
Triglyceride-glucose (TyG) index is an independent risk factor for cardiovascular diseases (CVD). Our study determined the trends of the TyG index and its relationship to predicted CVD risk among patients with type 2 diabetes (T2D). A serial cross-sectional study was conducted including 63,815 participants with T2D aged 30-74 years without a history of CVD. The predicted CVD risk was based on the Framingham Heart Study (FHS). The receiver operating characteristic (ROC) curve was utilized for identifying the cutoff point of TyG index to predict intermediate-to-high CVD risk. The relationship between TyG index and predicted CVD risk was tested using linear and logistic regression. Decreasing trends of TyG index were observed between 2014 and 2018 (p < 0.001). ROC curve analysis of the TyG index indicated an AUC of 0.57 (95% CI 0.56-0.57, p < 0.001) in predicting intermediate-to-high predicted CVD risk, with a cutoff value of TyG index > 9.2 (sensitivity of 55.7%, specificity of 46.8%). An independent relationship between the TyG index and predicted CVD risk was observed. High TyG index was independently associated with intermediate-to-high predicted CVD risk. From our study, the TyG index was positively related to predicted 10-year CVD risk. However, the predictive ability of the TyG index in predicting the intermediate-to-high predicted 10-year CVD risk among patients with T2D remained questionable.
甘油三酯-葡萄糖（TyG）指数是心血管疾病（CVD）的独立危险因素。本研究旨在确定 2 型糖尿病（T2D）患者 TyG 指数的趋势及其与预测 CVD 风险的关系。这是一项连续的横断面研究，共纳入了 63815 名年龄在 30-74 岁、无 CVD 病史的 T2D 患者。预测 CVD 风险基于弗雷明汉心脏研究（FHS）。采用受试者工作特征（ROC）曲线确定 TyG 指数预测中高危 CVD 风险的截断点。采用线性和逻辑回归检验 TyG 指数与预测 CVD 风险之间的关系。结果显示，2014 年至 2018 年期间 TyG 指数呈下降趋势（p<0.001）。ROC 曲线分析显示，TyG 指数预测中高危 CVD 风险的 AUC 为 0.57（95%CI 0.56-0.57，p<0.001），截断值为 TyG 指数>9.2（敏感度为 55.7%，特异度为 46.8%）。TyG 指数与预测 CVD 风险之间存在独立关系。高 TyG 指数与中高危预测 CVD 风险独立相关。综上，TyG 指数与预测 10 年 CVD 风险呈正相关。然而，TyG 指数预测 T2D 患者中高危预测 10 年 CVD 风险的能力仍存在疑问。
