Department of Cardiology, Affiliated Hospital of North China University of Science and Technology, No. 73 Jianshe South Road, Lubei District, Tangshan, 063000, China.
Department of Cardiology, KaiLuan General Hospital, Tangshan, China.
BMC Public Health. 2024 Oct 9;24(1):2750. doi: 10.1186/s12889-024-20243-z.
This study explores the intricate relationship between Chronic Kidney Disease (CKD), the Triglyceride-Glucose (TyG) index, and Cardiovascular Disease (CVD) in a U.S. adult population. It focuses on understanding how the TyG index, as a marker of insulin resistance, relates to cardiovascular risk in the presence of CKD.
A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. The study involved classifying stages of CKD, calculating the TyG index, and applying statistical analyses including logistic regression.
The investigation revealed that individuals with CKD, who comprised 49% males with an average age of 47 years, exhibited a higher incidence of CVD. The study demonstrated that before adjusting for the TyG index, the odds ratio (OR) for the association between CKD and CVD was 1.77. Importantly, the TyG index was found to mediate 10% of the association between CKD and CVD. Moreover, a significant synergistic interaction was observed between a high TyG index and CKD, with the combined presence of these conditions increasing the risk ratio for CVD to 3.01.
The findings highlight the crucial role of insulin resistance in the link between CKD and CVD. The paper discusses the implications of chronic inflammation and endothelial dysfunction in CKD patients and the importance of the TyG index in assessing cardiovascular risk.
本研究探讨了美国成年人慢性肾脏病（CKD）、甘油三酯-葡萄糖（TyG）指数与心血管疾病（CVD）之间的复杂关系。本研究重点关注 TyG 指数作为胰岛素抵抗标志物，在 CKD 存在的情况下与心血管风险的关系。
本研究采用 1999 年至 2018 年期间国家健康和营养检查调查（NHANES）的数据进行横断面分析。研究包括对 CKD 分期、计算 TyG 指数以及应用逻辑回归等统计分析进行分类。
研究结果表明，患有 CKD 的个体（男性占 49%，平均年龄为 47 岁）发生 CVD 的几率更高。研究表明，在未调整 TyG 指数的情况下，CKD 和 CVD 之间的关联的比值比（OR）为 1.77。重要的是，TyG 指数介导了 CKD 和 CVD 之间 10%的关联。此外，还观察到 TyG 指数高与 CKD 之间存在显著的协同交互作用，这些条件的共同存在使 CVD 的风险比增加到 3.01。
这些发现强调了胰岛素抵抗在 CKD 和 CVD 之间的联系中的关键作用。本文讨论了慢性炎症和 CKD 患者内皮功能障碍的影响，以及 TyG 指数在评估心血管风险方面的重要性。
