Department of Microbiology, Virology, and Immunology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Bull Exp Biol Med. 2023 Jul;175(3):358-361. doi: 10.1007/s10517-023-05867-2. Epub 2023 Aug 10.
Antimicrobial activity of milk whey in different mammals against Candida albicans yeast cells was studied by a spectrophotometric method. The activity increased in the order goat→horse→camel→cow→human→mouse. The level of whey activity in mice was higher by 3 and 10 times than in humans and goats, respectively. Similar changes were noted for activity of the whey fraction <100 kDa containing a complex of antimicrobial polypeptides, and there was a direct correlation between these two parameters (r=0.881; p<0.05). The total activity of whey had a high degree of correlation with the content of serum albumin (r=0.992); in mice, the level of serum albumin in the milk whey was close to that in blood serum. Interspecific differences between the activity of whey in mammals may be associated with qualitative and quantitative variability of the antimicrobial polypeptide composition, as well as their synergistic or antagonistic interaction with each other.
研究了不同哺乳动物乳清对白色念珠菌酵母细胞的抗菌活性，采用分光光度法。活性按山羊>马>骆驼>奶牛>人>鼠的顺序增加。与人和山羊相比，小鼠乳清的活性水平分别高出 3 倍和 10 倍。乳清中 <100 kDa 的含有抗菌多肽复合物的乳清部分的活性也有类似的变化，这两个参数之间存在直接相关性（r=0.881；p<0.05）。乳清的总活性与血清白蛋白含量高度相关（r=0.992）；在小鼠中，乳清中的血清白蛋白水平接近血清中的水平。哺乳动物乳清抗菌活性的种间差异可能与抗菌多肽组成的定性和定量变异性以及它们之间的协同或拮抗相互作用有关。
