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[居里研究所视网膜肿瘤的保守治疗。129例采用斯塔拉德盘和电子治疗的5年眼科结果]

[Conservative treatment of tumors of the retina at the Curie Institute. 5-year ophthalmologic results of 129 cases treated with the Stallard disc and electrons].

作者信息

Haye C, Schlienger P, Calle R, Vilcoq J R, Blaszka B

出版信息

Bull Cancer. 1986;73(3):260-70.

PMID:3756362
Abstract

The authors report a retrospective study of 129 children with retino-blastoma treated from 1963 to 1977 at the Institute Curie by enucleation of the worst eye and conservative irradiation of the other eye; this irradiation was performed either with Stallard plaque (19 cases) or with electrons (110 cases). In 8 familial cases no enucleation was performed. T.E.M. was used from 1964 to 1973 and iterative photocoagulation has been performed since 1968. Five years absolute NED survival rate was 68% (88/129 children). In these 88 children, 94 eyes were irradiated. Ophthalmological results were as follows: 21 eyes were enucleate secondarily (20/21 were tumoral); the attempt of ocular conservation was succeeded in 78% of the cases: 73 of the 94 irradiated eyes were cured; among these 73 cured eyes, 4 had complications and 15 had sequelae; the others 54 eyes were normal; only 5 eyes escaped ophthalmological survey; for the other 68 eyes vision was evaluated: 2 eyes (3%) were functional but vision could not be measured; 10 (14%) had less than 1/10 of visual acuity; 14 (19%) had vision at least equal to 1/10 but less than 5/10; 42 (57%) had 5/10 or more. 62% of all irradiated eyes (58/94) and 79% of conservated eyes (58/73) had "useful vision". Results are discussed and compared with these published by other teams; the authors try to determine elements of visual prognosis.

摘要

作者报告了一项回顾性研究,该研究针对1963年至1977年期间在居里研究所接受治疗的129例视网膜母细胞瘤患儿,对病情较重的眼睛进行眼球摘除,对另一只眼睛进行保守性放射治疗;这种放射治疗采用施塔拉德敷贴器(19例)或电子束(110例)进行。在8例家族性病例中未进行眼球摘除。1964年至1973年使用透射电子显微镜,自1968年起进行反复光凝治疗。五年无疾病进展生存率为68%(129例患儿中的88例)。在这88例患儿中,94只眼睛接受了放射治疗。眼科结果如下:21只眼睛后来被摘除(21只中的20只为肿瘤性);保眼尝试在78%的病例中成功:94只接受放射治疗的眼睛中有73只治愈;在这73只治愈的眼睛中,4只出现并发症,15只出现后遗症;其余54只眼睛正常;只有5只眼睛未接受眼科检查;对另外68只眼睛的视力进行了评估:2只眼睛(3%)功能正常但无法测量视力;10只眼睛(14%)视力低于1/10;14只眼睛(19%)视力至少等于1/10但低于5/10;42只眼睛(57%)视力为5/10或更高。所有接受放射治疗的眼睛中有62%(58/94)和保眼的眼睛中有79%(58/73)具有“有用视力”。对结果进行了讨论,并与其他团队发表的结果进行了比较;作者试图确定视觉预后的因素。

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