Haye C, Schlienger P, Calle R, Vilcoq J R, Blaszka B
Bull Cancer. 1985;72(2):87-98.
The authors report a retrospective study of 129 children with retinoblastoma treated from 1963 to 1977 at the Institut Curie by enucleation of the worst eye and conservative irradiation of the other eye; this irradiation was performed either with Stallard plaque (19 cases) or with electrons (110 cases). In 8 familial cases, no enucleation has been performed. T.E.M. was used from 1964 to 1973 and iterative photocoagulation since 1968. With a 5 years follow up, 88 children (68%) are living NED, 6 are lost. There was 34 treatment failures (26%) and 1 death from second malignant tumor. At 10 and 15 years, the results are stable despite the occurrence of two other second primary tumors. Irradiation preserved 73/94 (78%) of the irradiated eyes. The technical aspects of the radiotherapy with electrons and both ocular and vital prognostic factors are discussed.
作者报告了一项回顾性研究,该研究针对1963年至1977年期间在居里研究所接受治疗的129例视网膜母细胞瘤患儿,对病情较重的眼睛进行眼球摘除术,并对另一只眼睛进行保守放疗;这种放疗采用施塔拉德敷贴器(19例)或电子束(110例)进行。在8例家族性病例中,未进行眼球摘除术。1964年至1973年使用透射电子显微镜,自1968年起采用反复光凝治疗。经过5年随访,88名患儿(68%)无疾病生存,6名失访。有34例治疗失败(26%),1例死于第二原发恶性肿瘤。在10年和15年时,尽管又出现了另外两例第二原发肿瘤,但结果保持稳定。放疗使94只受照射眼睛中的73只(78%)得以保留。文中讨论了电子束放疗的技术方面以及眼部和重要的预后因素。