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一项药师主导的干预措施针对 2 型糖尿病成人患者的药物减量和改善心脏代谢药物的使用情况的效果评价。

Process evaluation of a pharmacist-led intervention aimed at deprescribing and appropriate use of cardiometabolic medication among adult people with type 2 diabetes.

机构信息

SIR Institute for Pharmacy Practice and Policy, Leiden, The Netherlands.

Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

出版信息

Basic Clin Pharmacol Toxicol. 2024 Jan;134(1):83-96. doi: 10.1111/bcpt.13931. Epub 2023 Sep 5.

Abstract

BACKGROUND

A quasi-experimental study investigated a pharmacist-led intervention aimed at deprescribing and medication management among adult patients with type 2 diabetes at risk of hypoglycaemia.

OBJECTIVE

This study aimed to evaluate the process of implementing the intervention consisting of a tailored clinical medication review (CMR) supported by a training and a toolbox.

METHODS

Mixed-methods study based on the Grant framework, including the domains "recruitment," "delivery of intervention" and "response" of pharmacists and patients. Data collected were administrative logs, semi-structured observations of patient consultations (n = 8), interviews with pharmacists (n = 16) and patient-reported experience measure (PREM) questionnaires (n = 66).

RESULTS

Tailored CMRs were conducted largely as intended for 90 patients from 14 pharmacies. Although patient selection based on a medication-derived hypoglycaemia risk score was considered useful, pharmacists experienced barriers to proposing deprescribing in patients with recent medication changes, without current hypoglycaemic events, or treated by medical specialists. The training and toolbox were evaluated positively by the pharmacists. Overall, patients were satisfied with the CMR.

CONCLUSION

Pharmacists and patients valued the CMR focusing on deprescribing and medication management. To optimize implementation and effectiveness of the intervention, improvements can be made to the patient selection, pharmacist training and the collaboration between healthcare professionals.

摘要

背景

一项准实验研究调查了一项由药剂师主导的干预措施,旨在减少 2 型糖尿病且有低血糖风险的成年患者的用药并进行药物管理。

目的

本研究旨在评估一项干预措施的实施过程,该干预措施包括由培训和工具包支持的个性化临床药物评估(CMR)。

方法

基于 Grant 框架的混合方法研究,包括药剂师和患者的“招募”、“干预措施的提供”和“反应”领域。收集的数据包括行政记录、对 8 名患者咨询的半结构化观察、对 16 名药剂师的访谈以及 66 名患者报告的体验测量(PREM)问卷。

结果

为 14 家药店的 90 名患者进行了个性化 CMR,但并未完全按照预期进行。尽管基于药物导致低血糖风险评分的患者选择被认为是有用的,但药剂师在为近期药物变化、无当前低血糖事件或由医学专家治疗的患者提出减少用药时遇到了障碍。培训和工具包得到了药剂师的积极评价。总体而言,患者对 CMR 感到满意。

结论

药剂师和患者都重视专注于减少用药和药物管理的 CMR。为了优化干预措施的实施和有效性,可以改进患者选择、药剂师培训以及医疗保健专业人员之间的合作。

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