Dische S, Saunders M I, Bennett M H, Dunphy E P, Des Rochers C, Stratford M R, Minchinton A I, Wardman P
Br J Radiol. 1986 Sep;59(705):911-7. doi: 10.1259/0007-1285-59-705-911.
Both Ro 03-8799 and misonidazole were administered to six patients before tumour sampling. Using similar doses, tumour concentrations of Ro 03-8799 were approximately double those of misonidazole. Examination of the data with regard to the relative sensitising efficiencies of these two compounds gives us, as a conservative estimate, a factor of 1.6 in favour of Ro 03-8799. From these observations it is predicted that, when given with radiotherapy in a 25-fraction course Ro 03-8799, is likely to be at least five times more effective as a hypoxic cell sensitiser than misonidazole.
在对六名患者进行肿瘤采样前，分别给他们使用了Ro 03-8799和米索硝唑。使用相似剂量时，Ro 03-8799在肿瘤中的浓度约为米索硝唑的两倍。对这两种化合物相对致敏效率的数据进行分析后，作为保守估计，我们得出Ro 03-8799的优势系数为1.6。根据这些观察结果预测，在25次分割疗程的放疗中同时使用时，Ro 03-8799作为乏氧细胞增敏剂的效果可能至少是米索硝唑的五倍。
