Omura M
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Nov;35(11):1972-80.
Misonidazole was histologically evaluated as a hypoxic cell radiosensitizer to a transplantable human cervical cancer in nude mice (Yumoto Strain). Acute exposure of X-ray (Lineac, a 1,000 rad dose) was applied to the cervical cancer. Tumor Volume (T.V. growth curve). Radiation alone induced an 8-10 day growth delay, but radiation therapy with Misonidazole induced a 10-12 day growth delay. Tumor Cord (T.C.). This idea originated with Thomlinson and Gray. They found that the radius of a tumor cord was always same. On the radiation therapy with Misonidazole, the tumor cords decreased faster than with radiation therapy alone. Tumor cellular Density (T.D.). This is the cell population per unit of area. We separated the tumor cords with two blocks, one near and one far from the blood vessel. T.D. decreased faster in the case of radiation with Misonidazole, and on the far square, radiation effectiveness was more obvious than on the near one. In addition, a histological examination proved that the Misonidazole affected hypoxic elements of the tumor, and this finding was proved in 48 hours after radiation. But aerobic elements of the tumor survived and were slightly changed histologically. In conclusion, Misonidazole proved to be an effective hypoxic cell sensitizer for human cervical cancer in radiation therapy.
在裸鼠（汤本株）移植的人类宫颈癌中，对米索硝唑进行了组织学评估，以确定其作为乏氧细胞放射增敏剂的效果。对宫颈癌进行了X射线（直线加速器，1000拉德剂量）的急性照射。肿瘤体积（T.V.生长曲线）。单独放疗导致肿瘤生长延迟8 - 10天，但米索硝唑联合放疗导致肿瘤生长延迟10 - 12天。肿瘤索条（T.C.）。这个概念由汤姆林森和格雷提出。他们发现肿瘤索条的半径总是相同的。使用米索硝唑进行放疗时，肿瘤索条比单独放疗时减少得更快。肿瘤细胞密度（T.D.）。这是单位面积内的细胞数量。我们用两个区域分隔肿瘤索条，一个靠近血管，一个远离血管。在使用米索硝唑放疗的情况下，T.D.下降得更快，并且在远离血管的区域，放疗效果比靠近血管的区域更明显。此外，组织学检查证明米索硝唑影响肿瘤的乏氧成分，并且这一发现于放疗后48小时得到证实。但是肿瘤的有氧成分存活下来，并且在组织学上有轻微变化。总之，米索硝唑被证明是人类宫颈癌放疗中一种有效的乏氧细胞增敏剂。
